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Table 1 Patient characteristics by quartiles of FIB-4 at baseline

From: Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort study

FIB-4 Q1(0.218–1.606) Q2(1.607–2.832) Q3(2.833–5.373) Q4(> 5.376)
N 991 990 990 991
AKI stage, n (%)
Stage 1 442 (44.601) 432 (43.636) 393 (39.697) 358 (36.125)
Stage 2 327 (32.997) 318 (32.121) 331 (33.434) 354 (35.721)
Stage 3 222 (22.402) 240 (24.242) 266 (26.869) 279 (28.153)
Age 54.217 (18.135) 64.938 (16.388) 68.903 (15.364) 70.277 (14.536)
Gender(male), n (%) 584 (58.930) 585 (59.091) 580 (58.586) 589 (59.435)
Weight (Kg) 85.675 (26.086) 83.439 (24.102) 81.689 (24.089) 80.030 (20.430)
Admission type, n (%)
MICU 517 (52.17) 478 (48.283) 429 (43.333) 386 (38.951)
CCU 152 (15.338) 184 (18.586) 208 (21.01) 205 (20.686)
SICU 144 (14.531) 133 (13.434) 121 (12.222) 115 (11.604)
Others 178 (17.962) 195 (19.697) 232 (23.434) 285 (28.759)
Ethnicity, n (%)
White 652 (65.79) 690 (69.70) 698 (70.51) 670 (67.61)
Black 117 (11.81) 105 (10.61) 87 (8.79) 82 (8.27)
Asian 24 (2.42) 31 (3.13) 27 (2.73) 22 (2.22)
Others 198 (19.98) 164 (16.57) 178 (17.98) 217 (21.90)
ICU intervention
Mechanical ventilation
(first24hours), n (%)
274.138 (71.222) 221.546 (67.182) 187.199 (69.434) 152.168 (65.734)
Vasopressor (first24hours), n (%) 25(19–38) 37 (24–59) 58(36–101) 153(75–318)
Renal replacement therapy, n (%) 24 (17–42) 28 (17–50) 35(19–74) 63 (30–159)
Fluid input
(first 48 h) (ml)
477 (48.133) 479 (48.384) 569 (57.475) 608 (61.352)
  266 (26.842) 294 (29.697) 412 (41.616) 501 (50.555)
  92 (9.284) 109 (11.01) 106 (10.707) 155 (15.641)
  1737(492–3750) 1722(531–3373) 1962 (737–3615) 2084 (856–4059)
Fluid balance
Volume (first 24 h) (ml) 1239 (− 367–3484) 1214 (− 165–3692) 1744(45–4255) 2448 (407–5585)
Positive, n (%) 658 (68.973) 679 (72.311) 717 (75.793) 757 (80.361)
Volume (second 24 h) (ml) 220(− 909–2119) 280 (− 653–1822) 600(− 526–2259) 713 (− 713–2783)
Positive, n (%) 442 (54.907) 478 (58.01) 526 (62.619) 545 (63.892)
Laboratory
Hemoglobin(g/L) 18.484 (5.287) 19.633 (5.046) 20.870 (5.036) 21.491 (5.545)
WBC(10^9/L) 4 (2–6) 4.5 (3–7) 6(4–8) 7(5–10)
PH 5.5 (0–12) 7(3–13) 10 (5–15) 10(5–16)
PLT(10^9/L) 11.431 (2.179) 11.078 (2.082) 10.945 (2.11) 10.693 (2.2)
AST(u/L) 12(8.55–16.4) 11.4 (8.2–15.7) 11.45 (8–16.1) 11.3(8–16.4)
ALT(u/L) 7.350 (0.104) 7.339 (0.095) 7.334 (0.103) 7.328 (0.113)
Co-morbidities, n (%)
CHF 234 (23.613) 332 (33.535) 366 (36.970) 348 (35.116)
AFib 176 (17.76) 264 (26.667) 331 (33.434) 366 (36.932)
Chronic renal disease 140 (14.127) 182 (18.384) 197 (19.899) 187 (18.87)
COPD 107 (10.797) 125 (12.626) 117 (11.818) 112 (11.302)
CAD 172 (17.356) 254 (25.657) 287 (28.99) 353 (35.621)
Stoke 94 (9.485) 88 (8.889) 70 (7.071) 64 (6.458)
Malignancy 126 (12.714) 144 (14.545) 162 (16.364) 148 (14.934)
Sepsis 438 (44.198) 486 (49.091) 513 (51.818) 533 (53.784)
ARDS 52 (5.247) 54 (5.455) 58 (5.859) 59 (5.954)
Outcomes
In-hospital mortality, n (%) 86 (8.678%) 128 (12.929%) 174 (17.576%) 200 (20.182%)
28-day mortality, n (%) 93 (9.384%) 144 (14.545%) 178 (17.980%) 199 (20.081%)
90-day mortality, n (%) 143 (14.430%) 207 (20.909%) 268 (27.071%) 275 (27.750%)
  1. SAPSII score: was calculated within the first 24 h after the ICU admission using the value associated with the greatest severity of illness; SOFA score: Sequential Organ Failure Assessment; Elixhauser score: Elixhauser Comorbidity Index; WBC: white blood cell; CHF: congestive heart failure; PLT: platelet; AST: aspartate aminotransferase; ALT: alanine transaminase; AFib: atrial fibrillation; COPD: chronic obstructive pulmonary disease; CAD: coronary artery disease; ARDS: acute respiratory distress syndrome. The first values during the first day after ICU admission were recorded