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Table 2 Characteristics of the studies included in the meta-analysis

From: Association of HSD17B13 rs72613567: TA allelic variant with liver disease: review and meta-analysis

Study Cohort characteristics Country Total numbers Gender, (men%) Age (mean ± SD) Study design Genotyping Allele HWE Risk factors Matching variables
TA T
Stickel [11] HCC Swiss, German, Austrian, Italian, British 1031 91.0 62 ± 10 Case control study TaqMan 365 1697 YES Alcohol consumption Age, gender, BMI, PNPLA3 (rs738409)
  ALD   1653 84.0 48 ± 10    728 2578    
Yang [12] HCC France 178 83.0 64 Case control study TaqMan 86 270 YES Alcohol consumption Age, gender, PNPLA3 (rs738409)
  Viral hepatitis   459 68.0 55    316 602    
Fazio [13] HCC Italy 123 Case control study TaqMan 52 194 NO PNPLA3 (rs738409)
  NAFLD   241     98 384    
Abul-Husn [14] HCC USA 44 42.0 63 Case control study TaqMan 12 76 YES Alcohol consumption Age, gender, BMI
  NAFLD   435      106 764    
Scheiner [15] HCC Vienna 23 Case control study TaqMan 10 40 NO Alcohol consumption Age, gender, MELD, HVPG
  Viral hepatitis and NAFLD   464 74.0    204 720    
Abul-Husn [14] HCC USA 44 42.0 63 Case control study TaqMan 12 76 YES Alcohol consumption Age, gender, BMI
  Healthy controls   4279      1172 7386    
Yang [12] HCC France 1018 83.0 case control study TaqMan 692 1344 YES alcohol consumption Age, gender, PNPLA3 (rs738409)
  Healthy controls   503    402 604    
Fazio [13] HCC Italy 123 Case control study TaqMan 52 194 NO PNPLA3 (rs738409)
  Healthy controls   90     50 130    
Ting [16] NAFLD Malaya, China, India 223 52.5 55.65 ± 12.5 Case control study TaqMan 107 339 NO Age, gender, BMI, Blood pressure,
  Viral hepatitis   205 42.4 51.0 ± 12.5    139 271    
Di Sessa [17] NAFLD Italy 318 53.3 10.7 ± 2.9 Case control study TaqMan 200 436 YES NO Age, gender, BMI,
  Healthy controls   366 50.5 10.3 ± 2.3    334 398    
Fazio [13] NAFLD Italy 151 Case control study TaqMan 48 254 - NO PNPLA3 (rs738409)
  Healthy controls   90     50 130    
Abul-Husn [14] NAFLD USA 210 42.0 63 Case control study TaqMan 46 374 YES alcohol consumption Age, gender, BMI
  Healthy controls   4279      1172 7386    
Scheiner [15] NAFLD Vienna 202 76.0 59 ± 10 Case control study TaqMan 89 315 NO NO Age, gender, MELD, HVPG
  Viral hepatitis   285 74.0 52 ± 9    125 445