Skip to main content

Table 3 Association of the ABCG8 rs11887534 variant and sex with gallstones in the study participants

From: Risk of gallstones based on ABCG8 rs11887534 single nucleotide polymorphism among Taiwanese men and women

Variables OR 95% CI P-value
ABCG8 rs11887534 genotype, sex     
 ABCG8 rs11887534 GG, men (reference)
 ABCG8 rs11887534 GC + CC, men 1.598 0.941 2.714 0.0827
 ABCG8 rs11887534 GG, women 1.304 1.087 1.565 0.0043
 ABCG8 rs11887534 GC + CC, women 2.291 1.514 3.467 < .0001
Age 1.050 1.042 1.058 < .0001
Regular exercise     
 No (reference)
 Yes 0.885 0.769 1.020 0.0918
Cigarette smoking     
 No (reference)
 Yes 1.161 0.950 1.419 0.1448
Alcohol drinking     
 No (reference)
 Yes 0.997 0.771 1.288 0.9798
BMI     
 Normal (reference)
 Underweight 0.846 0.506 1.414 0.5239
 Overweight 1.159 0.987 1.360 0.0712
 Obesity 1.104 0.913 1.335 0.3057
Family history of gallstones     
 No (reference)
 Yes 1.683 1.360 2.083 < .0001
Diabetes     
 No (reference)
 Yes 1.128 0.927 1.373 0.2302
Total bilirubin 1.823 1.465 2.269 < .0001
AST 0.988 0.977 0.998 0.0213
ALT 1.011 1.005 1.017 0.0004
HDL-C (mg/dL) 0.985 0.979 0.991 < .0001
LDL-C (mg/dL) 0.998 0.996 1.000 0.1123
TG (mg/dL) 0.999 0.998 1.000 0.0592
Dietary fat score 1.000 0.992 1.007 0.8959
  1. OR odds ratio, CI confidence interval, ABCG8 ATP-binding cassette subfamily G Member 8, BMI body mass index, AST aspartate aminotransferase, ALT alanine transaminase, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, TG triglyceride