Table 1 Baseline profiles of the study participants stratified by sex
Variables | Women (n = 13,880) | Men (n = 7388) | P-value |
|---|---|---|---|
Gallstone | Â | Â | 0.1043 |
 No | 13,291 (95.76) | 7039 (95.28) |  |
 Yes | 589 (4.24) | 349 (4.72) |  |
ABCG8 rs11887534 genotype | Â | Â | 0.4880 |
 GG | 13,462 (96.99) | 7178 (97.16) |  |
 GC + CC | 418 (3.01) | 210 (2.84) |  |
Age (years) | 49.756 ± 0.088 | 49.868 ± 0.128 | 0.4702 |
Regular exercise | Â | Â | 0.0023 |
 No | 8032 (57.87) | 4115 (55.70) |  |
 Yes | 5848 (42.13) | 3273 (44.30) |  |
Cigarette smoking |  |  | < .0001 |
 No | 13,272 (95.62) | 4149 (56.16) |  |
 Yes | 608 (4.38) | 3239 (43.84) |  |
Alcohol drinking |  |  | < .0001 |
 No | 13,571 (97.77) | 5992 (81.10) |  |
 Yes | 309 (2.23) | 1396 (18.90) |  |
BMI (kg/m2) |  |  | < .0001 |
 18.5 ≤ BMI < 24 (Normal BMI) | 7944 (57.23) | 2666 (36.09) |  |
 BMI < 18.5 (Underweight) | 531 (3.83) | 83 (1.12) |  |
 24 ≤ BMI < 27 (Overweight) | 3280 (23.63) | 2698 (36.52) |  |
 BMI ≥ 27 (Obesity) | 2125 (15.31) | 1941 (26.27) |  |
Family history of gallstones | Â | Â | 0.0153 |
 No | 12,812 (92.31) | 6887 (93.22) |  |
 Yes | 1068 (7.69) | 501 (6.78) |  |
Diabetes |  |  | < .0001 |
 No | 12,759 (91.92) | 6390 (86.49) |  |
 Yes | 1121 (8.08) | 998 (13.51) |  |
Total bilirubin (mg/dL) | 0.6138 ± 0.002 | 0.7516 ± 0.004 | < .0001 |
AST (U/L) | 23.1276 ± 0.100 | 26.2884 ± 0.173 | < .0001 |
ALT (U/L) | 20.8680 ± 0.147 | 29.9571 ± 0.274 | < .0001 |
HDL-C (mg/dL) | 58.3463 ± 0.113 | 48.1481 ± 0.131 | < .0001 |
LDL-C (mg/dL) | 120.7000 ± 0.271 | 122.3000 ± 0.368 | 0.0003 |
TG (mg/dL) | 102.3000 ± 0.608 | 137.000 ± 1.288 | < .0001 |
Dietary fat score | 41.7411 ± 0.078 | 45.9518 ± 0.111 | < .0001 |
Menopause | Â | Â | Â |
 No | 6937 (49.98) | – | – |
 Yes | 6943 (50.02) | – | – |
Hormone use | Â | Â | Â |
 No | 11,721 (84.45) | – | – |
 Yes | 2159 (15.55) | – | – |