Variables
|
Women (n = 13,880)
|
Men (n = 7388)
|
P-value
|
---|
Gallstone
| | |
0.1043
|
No
|
13,291 (95.76)
|
7039 (95.28)
| |
Yes
|
589 (4.24)
|
349 (4.72)
| |
ABCG8 rs11887534 genotype
| | |
0.4880
|
GG
|
13,462 (96.99)
|
7178 (97.16)
| |
GC + CC
|
418 (3.01)
|
210 (2.84)
| |
Age (years)
|
49.756 ± 0.088
|
49.868 ± 0.128
|
0.4702
|
Regular exercise
| | |
0.0023
|
No
|
8032 (57.87)
|
4115 (55.70)
| |
Yes
|
5848 (42.13)
|
3273 (44.30)
| |
Cigarette smoking
| | |
< .0001
|
No
|
13,272 (95.62)
|
4149 (56.16)
| |
Yes
|
608 (4.38)
|
3239 (43.84)
| |
Alcohol drinking
| | |
< .0001
|
No
|
13,571 (97.77)
|
5992 (81.10)
| |
Yes
|
309 (2.23)
|
1396 (18.90)
| |
BMI (kg/m2)
| | |
< .0001
|
18.5 ≤ BMI < 24 (Normal BMI)
|
7944 (57.23)
|
2666 (36.09)
| |
BMI < 18.5 (Underweight)
|
531 (3.83)
|
83 (1.12)
| |
24 ≤ BMI < 27 (Overweight)
|
3280 (23.63)
|
2698 (36.52)
| |
BMI ≥ 27 (Obesity)
|
2125 (15.31)
|
1941 (26.27)
| |
Family history of gallstones
| | |
0.0153
|
No
|
12,812 (92.31)
|
6887 (93.22)
| |
Yes
|
1068 (7.69)
|
501 (6.78)
| |
Diabetes
| | |
< .0001
|
No
|
12,759 (91.92)
|
6390 (86.49)
| |
Yes
|
1121 (8.08)
|
998 (13.51)
| |
Total bilirubin (mg/dL)
|
0.6138 ± 0.002
|
0.7516 ± 0.004
|
< .0001
|
AST (U/L)
|
23.1276 ± 0.100
|
26.2884 ± 0.173
|
< .0001
|
ALT (U/L)
|
20.8680 ± 0.147
|
29.9571 ± 0.274
|
< .0001
|
HDL-C (mg/dL)
|
58.3463 ± 0.113
|
48.1481 ± 0.131
|
< .0001
|
LDL-C (mg/dL)
|
120.7000 ± 0.271
|
122.3000 ± 0.368
|
0.0003
|
TG (mg/dL)
|
102.3000 ± 0.608
|
137.000 ± 1.288
|
< .0001
|
Dietary fat score
|
41.7411 ± 0.078
|
45.9518 ± 0.111
|
< .0001
|
Menopause
| | | |
No
|
6937 (49.98)
|
–
|
–
|
Yes
|
6943 (50.02)
|
–
|
–
|
Hormone use
| | | |
No
|
11,721 (84.45)
|
–
|
–
|
Yes
|
2159 (15.55)
|
–
|
–
|
- Continuous and categorical data are presented as mean ± standard error (SE) and n (%), respectively
- n = sample size, ABCG8 ATP-binding cassette subfamily G Member 8, BMI body mass index, AST aspartate aminotransferase, ALT alanine transaminase, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, TG triglyceride