Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus

Table 3 Cox proportional hazards model showing hazard ratios for colectomy (N = 87)

Variables at admission	Case number	Crude		Multivariable
Variables at admission	Case number	Hazard ratio [95% CI]	p value	Hazard ratio [95% CI]	p value
Sex
Female	37
Male	47	1.34 [0.59–3.06]	0.49	1.22 [0.51–2.97]	0.66
Age
< 39	40
≥ 39	44	0.94 [0.42–2.09]	0.88
Disease duration (years)
< 2.6	40
≥ 2.6	44	0.50 [0.22–1.15]	0.1
Disease type
Extensive	69	1.13 [0.39–3.31]	0.82	0.81 [0.29–2.27]	0.69
Left	15
Lichtiger index
< 13	29
≥ 13	55	1.40 [0.58–3.37]	0.46	2.20 [0.80–6.08]	0.13
Endoscopic score (UCEIS)
< 6	30
≥ 6	54	4.60 [1.37–15.46]	0.01	4.39 [1.40–13.78]	0.01
Hemoglobin (g/dL)
≤ 11.0	37	1.15 [0.51–2.56]	0.74
> 11.0	47
Albumin (g/dL)
≤ 3.1	41	1.60 [0.71–3.59]	0.26
> 3.1	43
C-reactive protein (mg/dL)
< 3.4	42
≥ 3.4	42	0.85 [0.38–1.90]	0.7	0.47 [0.19–1.13]	0.92
Erythrocytes sedimentation rates (mm)
< 53	41
≥ 53	43	2.20 [0.94–5.14]	0.07
Corticosteroid dependent
Yes	19	0.66 [0.23–1.93]	0.45
No	65
Biologic agent failure
Yes	23	2.18 [0.97–4.92]	0.06
No	61
Oral tacrolimus administration
Yes	22	2.24 [0.99–5.05]	0.05	4.13 [1.61–10.57]	< 0.01
No	62

Univariable analyses showed that higher endoscopic scores (ulcerative colitis endoscopic index of severity ≥ 6) were associated with a significantly higher hazard ratio of 4.60 [95% CI 1.37–15.46] (p = 0.01) for colectomy at 24 weeks. Multivariable analysis showed that higher endoscopic scores (ulcerative colitis endoscopic index of severity ≥ 6) and oral tacrolimus administration were associated with significantly higher hazard ratios for colectomy at 24 weeks of 3.98 [95% CI 1.11–14.28] (p = 0.03) and 3.35 [95% CI 1.17–9.56] (p = 0.02), respectively
CI confidence interval
UCEIS ulcerative colitis endoscopic index of severity

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