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Table 3 Cox proportional hazards model showing hazard ratios for colectomy (N = 87)

From: Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus

Variables at admission Case number Crude Multivariable
Hazard ratio [95% CI] p value Hazard ratio [95% CI] p value
Sex      
 Female 37     
 Male 47 1.34 [0.59–3.06] 0.49 1.22 [0.51–2.97] 0.66
Age      
 < 39 40     
 ≥ 39 44 0.94 [0.42–2.09] 0.88   
Disease duration (years)      
 < 2.6 40     
 ≥ 2.6 44 0.50 [0.22–1.15] 0.1   
Disease type      
 Extensive 69 1.13 [0.39–3.31] 0.82 0.81 [0.29–2.27] 0.69
 Left 15     
Lichtiger index      
 < 13 29     
 ≥ 13 55 1.40 [0.58–3.37] 0.46 2.20 [0.80–6.08] 0.13
Endoscopic score (UCEIS)      
 < 6 30     
 ≥ 6 54 4.60 [1.37–15.46] 0.01 4.39 [1.40–13.78] 0.01
Hemoglobin (g/dL)      
 ≤ 11.0 37 1.15 [0.51–2.56] 0.74   
 > 11.0 47     
Albumin (g/dL)      
 ≤ 3.1 41 1.60 [0.71–3.59] 0.26   
 > 3.1 43     
C-reactive protein (mg/dL)      
 < 3.4 42     
 ≥ 3.4 42 0.85 [0.38–1.90] 0.7 0.47 [0.19–1.13] 0.92
Erythrocytes sedimentation rates (mm)      
 < 53 41     
 ≥ 53 43 2.20 [0.94–5.14] 0.07   
Corticosteroid dependent      
 Yes 19 0.66 [0.23–1.93] 0.45   
 No 65     
Biologic agent failure      
 Yes 23 2.18 [0.97–4.92] 0.06   
 No 61     
Oral tacrolimus administration      
 Yes 22 2.24 [0.99–5.05] 0.05 4.13 [1.61–10.57] < 0.01
 No 62     
  1. Univariable analyses showed that higher endoscopic scores (ulcerative colitis endoscopic index of severity ≥ 6) were associated with a significantly higher hazard ratio of 4.60 [95% CI 1.37–15.46] (p = 0.01) for colectomy at 24 weeks. Multivariable analysis showed that higher endoscopic scores (ulcerative colitis endoscopic index of severity ≥ 6) and oral tacrolimus administration were associated with significantly higher hazard ratios for colectomy at 24 weeks of 3.98 [95% CI 1.11–14.28] (p = 0.03) and 3.35 [95% CI 1.17–9.56] (p = 0.02), respectively
  2. CI confidence interval
  3. UCEIS ulcerative colitis endoscopic index of severity