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Table 3 Comparison of genetic variants and other risk factors in patients with and without hepatic steatosis after liver transplantation

From: Variations in TM6SF2, PCSK9 and PCSK7 genes and risk of hepatic steatosis after liver transplantation: a cross-sectional study

Univariate Multivariate analysis
  Steatosis (+) Steatosis (−) P value OR 95% CI P value
Age (year) 49.83 ± 10.66 39.71 ± 12.81 < 0.001 1.144 0.904–1.448 0.253
Sex (male/female) 23/14 37/33 0.356    
Height (cm) 168.16 ± 10.47 166.73 ± 9.36 0.476    
Weight (kg) 80.83 ± 17.42 63.82 ± 11.58 < 0.001    
BMI (kg/m2) 28.59 ± 5.70 22.92 ± 3.54 < 0.001 1.074 0.768–1.503 0.675
HC (cm) 111.83 ± 11.50 97.29 ± 8.14 < 0.001 1.013 0.732–1.402 0.938
WC (cm) 104.49 ± 12.04 88.17 ± 9.29 < 0.001 1.114 0.827–1.501 0.476
AST (IU/L) 22.19 ± 12 26.41 ± 25.71 0.397    
ALT (IU/L) 24.76 ± 13.35 32.14 ± 34.70 0.267    
Alk.Phos (IU/L) 245.46 ± 105.77 212.35 ± 185.23 0.370    
PTDM 61.1% 16.7% < 0.001 0.168 0.008–3.647 0.256
Post-transplant HLP 47.2% 15.2% < 0.001 1.222 0.085–17.64 0.883
Post-transplant HTN 38.9% 18.8% 0.028 0.324 0.017–6.318 0.457
Rejection 36.7% 34.5% 0.839    
Mean prednisolone dose (mg) 8.26 ± 3.87 7.20 ± 3.74 0.379    
TM6SF2 genotype     1.237 0.083–18.473 0.878
 TT versus CC + CT 5.4% 0     
PCSK9 genotype
 GG versus AA + AG 2.7% 2.9% 0.954    
PCSK7 genotype
 TT versus CC + CT 35.2% 34.3% 0.935    
  1. BMI body mass index, AST aspartate aminotransferase, ALT alanine aminotransferase, Alk.Phos alkaline phosphatase, PTDM post-transplant diabetes mellitus, HLP hyperlipidemia, HTN hypertension, WC waist circumference, HC hip circumference, TM6SF2 transmembrane 6 super family 2, PCSK9 proprotein convertase subtilisin/kexin type 9, PCSK7 proprotein convertase subtilisin/kexin type 7