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Table 3 Comparison of genetic variants and other risk factors in patients with and without hepatic steatosis after liver transplantation

From: Variations in TM6SF2, PCSK9 and PCSK7 genes and risk of hepatic steatosis after liver transplantation: a cross-sectional study

Univariate

Multivariate analysis

 

Steatosis (+)

Steatosis (−)

P value

OR

95% CI

P value

Age (year)

49.83 ± 10.66

39.71 ± 12.81

< 0.001

1.144

0.904–1.448

0.253

Sex (male/female)

23/14

37/33

0.356

   

Height (cm)

168.16 ± 10.47

166.73 ± 9.36

0.476

   

Weight (kg)

80.83 ± 17.42

63.82 ± 11.58

< 0.001

   

BMI (kg/m2)

28.59 ± 5.70

22.92 ± 3.54

< 0.001

1.074

0.768–1.503

0.675

HC (cm)

111.83 ± 11.50

97.29 ± 8.14

< 0.001

1.013

0.732–1.402

0.938

WC (cm)

104.49 ± 12.04

88.17 ± 9.29

< 0.001

1.114

0.827–1.501

0.476

AST (IU/L)

22.19 ± 12

26.41 ± 25.71

0.397

   

ALT (IU/L)

24.76 ± 13.35

32.14 ± 34.70

0.267

   

Alk.Phos (IU/L)

245.46 ± 105.77

212.35 ± 185.23

0.370

   

PTDM

61.1%

16.7%

< 0.001

0.168

0.008–3.647

0.256

Post-transplant HLP

47.2%

15.2%

< 0.001

1.222

0.085–17.64

0.883

Post-transplant HTN

38.9%

18.8%

0.028

0.324

0.017–6.318

0.457

Rejection

36.7%

34.5%

0.839

   

Mean prednisolone dose (mg)

8.26 ± 3.87

7.20 ± 3.74

0.379

   

TM6SF2 genotype

   

1.237

0.083–18.473

0.878

 TT versus CC + CT

5.4%

0

    

PCSK9 genotype

 GG versus AA + AG

2.7%

2.9%

0.954

   

PCSK7 genotype

 TT versus CC + CT

35.2%

34.3%

0.935

   
  1. BMI body mass index, AST aspartate aminotransferase, ALT alanine aminotransferase, Alk.Phos alkaline phosphatase, PTDM post-transplant diabetes mellitus, HLP hyperlipidemia, HTN hypertension, WC waist circumference, HC hip circumference, TM6SF2 transmembrane 6 super family 2, PCSK9 proprotein convertase subtilisin/kexin type 9, PCSK7 proprotein convertase subtilisin/kexin type 7
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BMC Gastroenterology

ISSN: 1471-230X

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