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Table 4 Diagnostic performance of the indices for the differentiation of F3 and F4 from lower stages

From: FIB-4, APRI, and AST/ALT ratio compared to FibroScan for the assessment of hepatic fibrosis in patients with non-alcoholic fatty liver disease in Bandar Abbas, Iran

Indices AUC (95% CI) P value Optimal cut-off Sensitivity (%) Specificity (%) PPV (%) NPV (%) DA (%)
APRI 0.923 (0.876–0.970) < 0.001 0.702 84.1 88.2 66.1 95.3 87.3
FIB-4 0.913 (0.868–0.958) < 0.001 1.19 97.7 72.7 49.4 99.2 78.0
AST/ALT 0.720 (0.631–0.808) < 0.001 0.94 61.4 77.0 42.2 87.9 73.7
  1. AST aspartate aminotransferase, ALT alanine aminotransferase, CAP controlled attenuation parameter, APRI AST to platelet ratio index, FIB-4 fibrosis-4, AUC area under the curve, CI confidence interval, PPV positive predictive value, NPV negative predictive value, DA diagnostic accuracy