| n | Any cancer | GI cancer | Gastric cancer | ||||||
---|---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | ||
Incidence | ||||||||||
DDD no MHT | 96,548 | 1.000 | – | 0.4709†| 1.000 | – | 0.0002†| 1.000 | – | 0.0223†|
 ≤ 100 | 10,199 | 1.004 | 0.893, 1.128 | 0.9503 | 0.786 | 0.617, 1.002 | 0.0520 | 0.790 | 0.529, 1.180 | 0.2494 |
 100–300 | 4423 | 0.957 | 0.803, 1.139 | 0.6189 | 0.710 | 0.487, 1.035 | 0.0746 | 0.553 | 0.274, 1.116 | 0.0982 |
 300–600 | 2569 | 1.031 | 0.827, 1.284 | 0.7886 | 0.488 | 0.269, 0.884 | 0.0180 | 0.476 | 0.178, 1.278 | 0.1408 |
 ≥ 600 | 2352 | 0.876 | 0.681, 1.127 | 0.3031 | 0.545 | 0.292, 1.018 | 0.0568 | 0.709 | 0.293, 1.719 | 0.4471 |
Mortality | ||||||||||
DDD no MHT | 96,548 | 1.000 | – | 0.0052†| 1.000 | – | 0.0064†| 1.000 | – | 0.0264†|
 ≤ 100 | 10,199 | 0.663 | 0.470, 0.936 | 0.0194 | 0.514 | 0.300, 0.881 | 0.0156 | 0.445 | 0.139, 1.421 | 0.1718 |
 100–300 | 4423 | 0.891 | 0.563, 1.410 | 0.6224 | 0.798 | 0.410, 1.553 | 0.5067 | NAb | – | – |
 300–600 | 2569 | 0.852 | 0.455, 1.595 | 0.6165 | 0.481 | 0.154, 1.503 | 0.2081 | NAb | – | – |
 ≥ 600 | 2352 | 0.113 | 0.016, 0.803 | 0.0294 | 0.213 | 0.030, 1.521 | 0.1232 | NAb | – | – |
 | n | Colorectal cancer | Hepatobiliary cancer | Pancreas cancer | ||||||
---|---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | ||
Incidence | ||||||||||
DDD no MHT | 96,548 | 1.000 |  | 0.0069†| 1.000 |  | 0.1765†| 1.000 |  | 0.6680†|
 ≤ 100 | 10,199 | 0.843 | 0.568, 1.251 | 0.3970 | 0.639 | 0.355, 1.148 | 0.1338 | 0.825 | 0.330, 2.065 | 0.6813 |
 100–300 | 4423 | 0.643 | 0.331, 1.249 | 0.1926 | 0.866 | 0.407, 1.845 | 0.7095 | 1.538 | 0.556, 4.252 | 0.4065 |
 300–600 | 2569 | 0.626 | 0.258, 1.515 | 0.2988 | 0.443 | 0.110, 1.787 | 0.2527 | NAc | - | - |
 ≥ 600 | 2352 | 0.152 | 0.021, 1.082 | 0.0600 | 0.874 | 0.278, 2.743 | 0.8174 | 0.904 | 0.125, 6.558 | 0.9203 |
Mortality | ||||||||||
DDD no MHT | 96,548 | 1.000 |  | 0.0672†| 1.000 |  | 0.3329†| 1.000 |  | 0.8495†|
 ≤ 100 | 10,199 | NAb | – | – | 0.612 | 0.267, 1.403 | 0.2464 | 0.963 | 0.343, 2.705 | 0.9429 |
 100–300 | 4423 | NAb | – | – | 1.476 | 0.644, 3.380 | 0.3574 | 1.666 | 2.705, 5.411 | 0.3957 |
 300–600 | 2569 | 1.403 | 0.341, 5.762 | 0.6387 | NAb | – | – | NAb | – | – |
 ≥ 600 | 2352 | NAb | – | – | 0.633 | 0.088, 4.566 | 0.6505 | NAb | – | – |