PNPLA3 genotype and fibrosis-4 index predict cardiovascular diseases of Japanese patients with histopathologically-confirmed NAFLD

Table 6 Non-invasive predictors associated with the incidence of liver-related events

Factor	Category	Univariate			Multivariate
Factor	Category	Hazard ratio	(95% CI)	P value*	Hazard ratio	(95% CI)	P value*
FIB-4 index	< 2.67	1			1
	≥ 2.67	17.5	(4.49–67.8)	< 0.001	23.2	(5.66–95.1)	< 0.001
Gamma-glutamyl transpeptidase	< 219 U/L	1			1
	≥ 219 U/L	3.45	(1.11–10.7)	0.032	5.53	(1.70–18.0)	0.004

*Significance was determined using the Cox proportional hazard model. Variables that were statistically significant on univariate analysis were entered into multivariate analysis to identify significant independent factors. The characteristics of the 432 patients who were confirmed to have no previous or current liver-related events at NAFLD diagnosis were evaluated for the rate of development of liver-related events. During the follow-up period, 13 patients developed liver-related events. Liver-related events included liver cancer, hepatic encephalopathy, esophago-gastric varices, ascites, and jaundice

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