Table 2 Diagnostic performance of Fibrosis-4 (FIB-4) index for the detection of liver fibrosis
Overall (n = 477) | AUROC | (95%CI) | Fib-4 cut off | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|
Fibrosis stage 1–4 (n = 422) versus Fibrosis stage 0 (n = 55) | 0.75 | (0.69–0.81) | 1.30 | 56.4 | 78.2 | 95.2 | 18.9 |
2.67 | 20.9 | 98.2 | 98.9 | 13.9 | |||
Fibrosis stage 2–4 (n = 233) versus Fibrosis stage 0–1 (n = 244) | 0.84 | (0.80–0.87) | 1.30 | 79.8 | 73.8 | 74.4 | 79.3 |
2.67 | 36.1 | 98.0 | 94.4 | 61.6 | |||
Fibrosis stage 3–4 (n = 156) versus Fibrosis stage 0–2 (n = 321) | 0.85 | (0.81–0.88) | 1.30 | 88.5 | 65.1 | 55.2 | 92.1 |
2.67 | 46.2 | 94.7 | 80.9 | 78.4 | |||
Fibrosis stage 4 (n = 35) versus Fibrosis stage 0–3 (n = 442) | 0.90 | (0.87–0.94) | 1.30 | 100 | 51.4 | 14.0 | 100 |
2.67 | 82.9 | 86.4 | 32.6 | 98.5 |