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Table 2 Diagnostic performance of Fibrosis-4 (FIB-4) index for the detection of liver fibrosis

From: PNPLA3 genotype and fibrosis-4 index predict cardiovascular diseases of Japanese patients with histopathologically-confirmed NAFLD

Overall (n = 477) AUROC (95%CI) Fib-4 cut off Sensitivity (%) Specificity (%) PPV (%) NPV (%)
Fibrosis stage 1–4 (n = 422) versus Fibrosis stage 0 (n = 55) 0.75 (0.69–0.81) 1.30 56.4 78.2 95.2 18.9
    2.67 20.9 98.2 98.9 13.9
Fibrosis stage 2–4 (n = 233) versus Fibrosis stage 0–1 (n = 244) 0.84 (0.80–0.87) 1.30 79.8 73.8 74.4 79.3
    2.67 36.1 98.0 94.4 61.6
Fibrosis stage 3–4 (n = 156) versus Fibrosis stage 0–2 (n = 321) 0.85 (0.81–0.88) 1.30 88.5 65.1 55.2 92.1
    2.67 46.2 94.7 80.9 78.4
Fibrosis stage 4 (n = 35) versus Fibrosis stage 0–3 (n = 442) 0.90 (0.87–0.94) 1.30 100 51.4 14.0 100
    2.67 82.9 86.4 32.6 98.5
  1. AUROC, area under the receiver-operating characteristic curve; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value