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Table 3 Multiple linear regression analyses of FT3, FT4 and TSH with obesity indices, hepatic steatosis and HOMA-IR

From: Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults

Variables BMI (log-transformed) WHtR CAP FLI score (log-transformed) HOMA-IR (log-transformed)
β (95% CI) P-value β (95% CI) P-value β (95% CI) P-value β (95% CI) P-value β (95% CI) P-value
FT3
Model 1 0.044 (0.027–0.061)  < 0.001* 0.038 (0.017–0.059) 0.001* 25.11 (6.14–44.07) 0.010* 0.157 (0.083–0.232)  < 0.001* 0.134 (0.064–0.204)  < 0.001*
Model 2 0.028 (0.009–0.047) 0.005* 0.027 (0.002–0.051) 0.034* 22.36(0.09–44.63) 0.049* 0.093(0.008–0.178) 0.032* 0.09 (0.011–0.17) 0.011*
Model 3 0.024 (0.004–0.043) 0.020* 0.021 (−0.004–0.046) 0.104 25.45 (2.59–48.31) 0.030* 0.121 (0.049–0.194) 0.001* 0.091 (0.007–0.174) 0.034*
FT4
Model 1 0.007 (0.002–0.011) 0.004* 0.005 (0.000–0.010) 0.057 1.370 (−3.369–6.108) 0.567 0.015 (−0.005 −0.035) 0.143 −0.002 (−0.020–0.016) 0.841
Model 2 0.004 (−0.001–0.008) 0.092 0.002 (−0.003–0.007) 0.397 −0.363 (−5.371–4.644) 0.886 0.003 (−0.017–0.022) 0.784 −0.013 (−0.031–0.005) 0.167
Model 3 0.004 (−0.001–0.008) 0.126 0.002 (−0.004–0.008) 0.485 −1.176 (−6.939–4.587) 0.685 0.007 (−0.011–0.025) 0.436 −0.016 (−0.036–0.004) 0.125
TSH
Model 1 −0.0004 (−0.009–0.008) 0.929 −0.002 (−0.012–0.007) 0.625 1.655 (−7.107–10.417) 0.708 −0.004 (−0.039–0.032) 0.832 0.001 (−0.033–0.035) 0.962
Model 2 −0.001 (−0.009–0.006) 0.710 −0.004 (−0.013–0.005) 0.431 2.333 (−6.367–11.032) 0.595 −0.003 (−0.034–0.029) 0.870 −0.003 (−0.035–0.029) 0.868
Model 3 −0.001 (−0.009–0.007) 0.768 −0.004 (−0.014–0.005) 0.329 3.206 (−6.003–12.415) 0.490 0.003 (−0.026 −0.031) 0.854 0.002 (−0.030–0.035) 0.893
  1. Model1: NO adjustment
  2. Model2: Adjustment for age, sex, occasional drinking, SBP, DBP and TSH
  3. Model3: Adjustment for age, sex, occasional drinking, SBP, DBP, TSH, TG, TC, HDL-c, and LDL-c
  4. BMI body mass index, WHtR waist-to-height ratio, HOMA-IR homeostatic model assessment of insulin resistance, FLI fatty liver index, CAP controlled attenuation parameter, FT3 free triiodothyronine, FT4 free thyroxine, TSH thyroid stimulating hormone
  5. *p < 0.05
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BMC Gastroenterology

ISSN: 1471-230X

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