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Table 3 Multiple linear regression analyses of FT3, FT4 and TSH with obesity indices, hepatic steatosis and HOMA-IR

From: Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults

Variables

BMI (log-transformed)

WHtR

CAP

FLI score (log-transformed)

HOMA-IR (log-transformed)

β (95% CI)

P-value

β (95% CI)

P-value

β (95% CI)

P-value

β (95% CI)

P-value

β (95% CI)

P-value

FT3

Model 1

0.044 (0.027–0.061)

 < 0.001*

0.038 (0.017–0.059)

0.001*

25.11 (6.14–44.07)

0.010*

0.157 (0.083–0.232)

 < 0.001*

0.134 (0.064–0.204)

 < 0.001*

Model 2

0.028 (0.009–0.047)

0.005*

0.027 (0.002–0.051)

0.034*

22.36(0.09–44.63)

0.049*

0.093(0.008–0.178)

0.032*

0.09 (0.011–0.17)

0.011*

Model 3

0.024 (0.004–0.043)

0.020*

0.021 (−0.004–0.046)

0.104

25.45 (2.59–48.31)

0.030*

0.121 (0.049–0.194)

0.001*

0.091 (0.007–0.174)

0.034*

FT4

Model 1

0.007 (0.002–0.011)

0.004*

0.005 (0.000–0.010)

0.057

1.370 (−3.369–6.108)

0.567

0.015 (−0.005 −0.035)

0.143

−0.002 (−0.020–0.016)

0.841

Model 2

0.004 (−0.001–0.008)

0.092

0.002 (−0.003–0.007)

0.397

−0.363 (−5.371–4.644)

0.886

0.003 (−0.017–0.022)

0.784

−0.013 (−0.031–0.005)

0.167

Model 3

0.004 (−0.001–0.008)

0.126

0.002 (−0.004–0.008)

0.485

−1.176 (−6.939–4.587)

0.685

0.007 (−0.011–0.025)

0.436

−0.016 (−0.036–0.004)

0.125

TSH

Model 1

−0.0004 (−0.009–0.008)

0.929

−0.002 (−0.012–0.007)

0.625

1.655 (−7.107–10.417)

0.708

−0.004 (−0.039–0.032)

0.832

0.001 (−0.033–0.035)

0.962

Model 2

−0.001 (−0.009–0.006)

0.710

−0.004 (−0.013–0.005)

0.431

2.333 (−6.367–11.032)

0.595

−0.003 (−0.034–0.029)

0.870

−0.003 (−0.035–0.029)

0.868

Model 3

−0.001 (−0.009–0.007)

0.768

−0.004 (−0.014–0.005)

0.329

3.206 (−6.003–12.415)

0.490

0.003 (−0.026 −0.031)

0.854

0.002 (−0.030–0.035)

0.893

  1. Model1: NO adjustment
  2. Model2: Adjustment for age, sex, occasional drinking, SBP, DBP and TSH
  3. Model3: Adjustment for age, sex, occasional drinking, SBP, DBP, TSH, TG, TC, HDL-c, and LDL-c
  4. BMI body mass index, WHtR waist-to-height ratio, HOMA-IR homeostatic model assessment of insulin resistance, FLI fatty liver index, CAP controlled attenuation parameter, FT3 free triiodothyronine, FT4 free thyroxine, TSH thyroid stimulating hormone
  5. *p < 0.05
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BMC Gastroenterology

ISSN: 1471-230X

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