| |
Univariate
|
Multivariate
|
|---|
|
HR
|
95% CI
|
P
|
HR
|
OR (95% CI)
|
P
|
|---|
|
Parameter (model 1)
|
|
Age (years)
|
1.030
|
1.016–1.045
|
< 0.001
| | | |
|
Ascites (Y:N)
|
3.882
|
2.380–6.330
|
< 0.001
| | | |
|
HE (Y:N)
|
9.931
|
6.445–15.302
|
< 0.001
|
5.129
|
3.209–8.199
|
< 0.001
|
|
WBC (109 /L)
|
1.150
|
1.114–1.187
|
< 0.001
| | | |
|
NLR
|
1.107
|
1.087–1.129
|
< 0.001
|
1.067
|
1.038–1.096
|
< 0.001
|
|
Platelets (109 /L)
|
0.996
|
0.992–0.999
|
0.025
| | | |
|
INR
|
1.925
|
1.728–2.145
|
< 0.001
|
1.487
|
1.310–1.687
|
< 0.001
|
|
TB (mg/dL)
|
1.050
|
1.034–1.067
|
< 0.001
| | | |
|
Albumin (g/L)
|
0.970
|
0.935–1.005
|
0.096
| | | |
|
Creatinine (mg/dL)
|
1.642
|
1.405–1.919
|
< 0.001
|
1.269
|
1.043–1.545
|
0.017
|
|
Sodium (mmol/L)
|
0.911
|
0.884–0.939
|
0.001
| | | |
|
Lactate (mmol/L)
|
1.282
|
1.214–1.354
|
< 0.001
|
1.192
|
1.107–1.283
|
< 0.001
|
|
Parameter (model 2)
| | |
|
NLR grade
|
4.725
|
3.364–6.636
|
< 0.001
|
3.506
|
2.481–4.955
|
< 0.001
|
|
INR grade
|
3.763
|
2.854–4.963
|
< 0.001
|
2.400
|
1.803–3.193
|
< 0.001
|
|
TB
grade
|
1.745
|
1.393–2.185
|
< 0.001
| | | |
|
Creatinine grade
|
2.166
|
1.547–3.032
|
< 0.001
|
1.727
|
1.278–2.335
|
< 0.001
|
|
Lactate grade
|
1.857
|
1.479–2.332
|
< 0.001
| | | |
|
HE grade
|
4.349
|
3.442–5.496
|
< 0.001
|
2.366
|
1.793–3.121
|
< 0.001
|
- HE hepatic encephalopathy, WBC white blood cell count, NLR neutrophil/lymphocyte ratio, INR international normalized ratio, TB total bilirubin, ACLF acute-on-chronic liver failure, HBV-ACLF hepatitis b related ACLF, AARC Asian Pacific Society for the Study of the Liver ACLF research consortium
- Model 1 was adjusted for common variables. Model 2 was adjusted for three risk grades of NLR and five AARC-ACLF-related variables (include INR, TB, creatinine, lactate, and HE). Three risk grades of INR (< 1.8, 1.8–2.5, and > 2.5), TB (< 15 mg/dL, 15–25 mg/dL, and > 25 mg/dL), creatinine (< 0.7 mg/dL, 0.7–1.5 mg/dL, and > 1.5 mg/dL), lactate (< 1.5 mmol/L, 1.5–2.5 mmol/L, and > 2.5 mmol/L), and HE (< 3.10, 3.10–4.78, and > 4.78) were divided per the AARC ACLF scoring system. The corresponding three grades of NLR (< 3.10, 3.10–4.78, and > 4.78) was divided per the upper limit of normal and the optimal cut-off value evaluated in the sensitivity analyses in this cohort
