A neutrophil-to-lymphocyte ratio-based prognostic model to predict mortality in patients with HBV-related acute-on-chronic liver failure

Table 2 Cox regression analysis for predictors of 90-day mortality in 290 patients with HBV-ACLF in the derivation cohort

HE hepatic encephalopathy, WBC white blood cell count, NLR neutrophil/lymphocyte ratio, INR international normalized ratio, TB total bilirubin, ACLF acute-on-chronic liver failure, HBV-ACLF hepatitis b related ACLF, AARC Asian Pacific Society for the Study of the Liver ACLF research consortium
Model 1 was adjusted for common variables. Model 2 was adjusted for three risk grades of NLR and five AARC-ACLF-related variables (include INR, TB, creatinine, lactate, and HE). Three risk grades of INR (< 1.8, 1.8–2.5, and > 2.5), TB (< 15 mg/dL, 15–25 mg/dL, and > 25 mg/dL), creatinine (< 0.7 mg/dL, 0.7–1.5 mg/dL, and > 1.5 mg/dL), lactate (< 1.5 mmol/L, 1.5–2.5 mmol/L, and > 2.5 mmol/L), and HE (< 3.10, 3.10–4.78, and > 4.78) were divided per the AARC ACLF scoring system. The corresponding three grades of NLR (< 3.10, 3.10–4.78, and > 4.78) was divided per the upper limit of normal and the optimal cut-off value evaluated in the sensitivity analyses in this cohort

ISSN: 1471-230X