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Table 2 Cox regression analysis for predictors of 90-day mortality in 290 patients with HBV-ACLF in the derivation cohort

From: A neutrophil-to-lymphocyte ratio-based prognostic model to predict mortality in patients with HBV-related acute-on-chronic liver failure

  Univariate Multivariate
HR 95% CI P HR OR (95% CI) P
Parameter (model 1)
 Age (years) 1.030 1.016–1.045  < 0.001    
 Ascites (Y:N) 3.882 2.380–6.330  < 0.001    
 HE (Y:N) 9.931 6.445–15.302  < 0.001 5.129 3.209–8.199  < 0.001
 WBC (109 /L) 1.150 1.114–1.187  < 0.001    
 NLR 1.107 1.087–1.129  < 0.001 1.067 1.038–1.096  < 0.001
 Platelets (109 /L) 0.996 0.992–0.999 0.025    
 INR 1.925 1.728–2.145  < 0.001 1.487 1.310–1.687  < 0.001
 TB (mg/dL) 1.050 1.034–1.067  < 0.001    
 Albumin (g/L) 0.970 0.935–1.005 0.096    
 Creatinine (mg/dL) 1.642 1.405–1.919  < 0.001 1.269 1.043–1.545 0.017
 Sodium (mmol/L) 0.911 0.884–0.939 0.001    
 Lactate (mmol/L) 1.282 1.214–1.354  < 0.001 1.192 1.107–1.283  < 0.001
 Parameter (model 2)   
 NLR grade 4.725 3.364–6.636  < 0.001 3.506 2.481–4.955  < 0.001
 INR grade 3.763 2.854–4.963  < 0.001 2.400 1.803–3.193  < 0.001
 TB grade 1.745 1.393–2.185  < 0.001    
 Creatinine grade 2.166 1.547–3.032  < 0.001 1.727 1.278–2.335  < 0.001
 Lactate grade 1.857 1.479–2.332  < 0.001    
 HE grade 4.349 3.442–5.496  < 0.001 2.366 1.793–3.121  < 0.001
  1. HE hepatic encephalopathy, WBC white blood cell count, NLR neutrophil/lymphocyte ratio, INR international normalized ratio, TB total bilirubin, ACLF acute-on-chronic liver failure, HBV-ACLF hepatitis b related ACLF, AARC Asian Pacific Society for the Study of the Liver ACLF research consortium
  2. Model 1 was adjusted for common variables. Model 2 was adjusted for three risk grades of NLR and five AARC-ACLF-related variables (include INR, TB, creatinine, lactate, and HE). Three risk grades of INR (< 1.8, 1.8–2.5, and > 2.5), TB (< 15 mg/dL, 15–25 mg/dL, and > 25 mg/dL), creatinine (< 0.7 mg/dL, 0.7–1.5 mg/dL, and > 1.5 mg/dL), lactate (< 1.5 mmol/L, 1.5–2.5 mmol/L, and > 2.5 mmol/L), and HE (< 3.10, 3.10–4.78, and > 4.78) were divided per the AARC ACLF scoring system. The corresponding three grades of NLR (< 3.10, 3.10–4.78, and > 4.78) was divided per the upper limit of normal and the optimal cut-off value evaluated in the sensitivity analyses in this cohort