Fig. 6

Prognostic performance of the accepted ACLF scores and the mAARC ACLFs was compared using the area under the receiver operating curve (AUROC), and was stratified for their performance in 290 patients in the derivation cohort by a comparison of 28-day mortality and b comparison of 90-day mortality; for their performance in 204 patients in the validation cohort by c comparison of 28-day mortality and d comparison of 90-day mortality. The mAARC ACLFs was calculated using three risk levels of baseline NLR (< 3.10, 3.10–4.78, and > 4.78) instead of corresponding levels of lactate (< 1.5 mmol/L, 1.5–2.5 mmol/L, and > 2.5 mmol/L). The Hanley & McNeil method was used for AUROC comparisons. Abbreviations: NLR, neutrophil-to-lymphocyte ratio; ACLF, acute-on-chronic liver failure; CTP, Child-Turcotte-Pugh; MELD, model of end-stage liver disease; AARC ACLFs, Asian Pacific Society for the Study of the Liver ACLF research consortium ACLF score; mAARC ACLFs, modified AARC ACLFs