Skip to main content

Table 1 Baseline characteristics of ACLF patients

From: Soluble urokinase plasminogen activator receptor is associated with short-term mortality and enhanced reactive oxygen species production in acute-on-chronic liver failure

 

(A)ACLF (n = 216)

(B)ACLF-MOF (n = 66)

(C)CHB (n = 14)

(D)HC (n = 14)

p- value A vs B

Age (years), Mean (± SD)

47.1 ± 12.6

46.4 ± 13.5

43.1 ± 14.3

42 ± 10.1

0.69

Male (%)

185 (85.6)

57(86.4)

12(85.7%)

12(85.7%)

0.88

Etiology

    

0.07

 HBV (%)

191 (88.4)

64 (97)

14 (100)

–

 

 Others (%)

25 (11.6)

2 (3)

–

–

 

Clinical feature

     

 Ascites (%)

170 (78.7)

50 (75.8)

–

–

0.61

 Cirrhosis (%)

110 (50.9)

31 (47.0)

–

–

0.57

 UGIB (%)

18 (8.3)

8 (12.1)

–

–

0.35

 HRS (%)

5 (2.3)

9 (13.6)

–

–

 < 0.001

 HE (%)

7 (3.2)

24 (36.4)

–

–

 < 0.001

 SBP (%)

9 (4.2)

6 (9.1)

–

–

0.12

Bacterial or fungal infection (%)

23 (10.6)

12 (18.2)

–

–

0.10

 Sepsis (%)

1 (0.5)

2 (3.0)

–

–

0.27

Laboratory data

     

 suPAR (ng/mL), Median (IQR)

11.9 (9.06–15.5)

16.4 (11.4–23.6)

2.8 (2.2–4.0)

2.3 (2.0–2.9)

 < 0.001

 WBC (× 109/L), Median (IQR)

6.2 (4.8–8.7)

8.1 (6.1–12.6)

5.1 (4.3–6.1)

5.4 (4.2–6.8)

 < 0.001

 Platelets (× 109/L), Median (IQR)

101 (72–140)

122 (81–177)

150 (116–200)

160 (110–231)

0.05

 ALT (IU/L), Median (IQR)

190 (67–492)

267 (175–910)

45 (16–101)

18 (10–24)

0.001

 Albumin (g/L), Mean (± SD)

31.1 ± 4.3

31.7 ± 4.0

40.5 ± 3.5

42.7 ± 3.0

0.39

 Bilirubin (mg/dL), Median (IQR)

18.1 (12.7–24.3)

21.0 (15.2–26.6)

0.8 (0.5–1.0)

0.7 (0.4–0.9)

0.039

 INR, Median (IQR)

1.94 (1.73–2.30)

3.14 (2.7–3.7)

–

–

 < 0.001

 Creatinine (mg/dL), Median (IQR)

0.7 (0.6–0.9)

0.8 (0.7–1.1)

0.6 (0.5–0.7)

0.6 (0.5–0.7)

0.04

 Sodium (mmol/L), Mean (± SD)

137.2 ± 3.9

137.6 ± 4.8

140 ± 3.1

142 ± 2.0

0.56

Scores

     

 CTP, Mean (± SD)

10.8 ± 1.3

11.4 ± 1.7

–

–

0.007

 MELD, Mean (± SD)

21.9 ± 4.6

30.4 ± 6.5

–

–

 < 0.001

 SOFA, Mean (± SD)

8.6 ± 1.76

12.0 ± 1.4

–

–

 < 0.001

  1. ACLF acute-on-chronic liver failure; ACLF-MOF ACLF complicated with multi-organ failure; CHB chronic hepatitis B; HC healthy controls; UGIB upper gastrointestinal bleeding; HRS hepatorenal syndrome; HE hepatic encephalopathy; SBP spontaneous bacterial peritonitis; WBC white blood cell count; INR international normalized ratio; CTP Child—Turcotte-Pugh; MELD Model for End-stage Liver Disease; SOFA sequential organ failure assessment
Back to article page

BMC Gastroenterology

ISSN: 1471-230X

Contact us