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Table 2 Univariable and multivariable Cox‐proportional hazard model for overall survival in BCLC very-early stage hepatocellular carcinoma patients

From: Clinical outcomes of surgical resection versus radiofrequency ablation in very-early‐stage hepatocellular carcinoma: a propensity score matching analysis

Characteristics Univariate Cox regression analyses Multivariate Cox regression analyses
Unadjusted HR (95% CI) P-value Adjusted HR (95% CI) P-value
Treatment type (SR vs. RFA) 2.58 (1.56–4.25)  < 0.001 1.75 (1.08–3.11) 0.046
Male 1.20 (0.71–2.04) 0.501   
Age (≥ 60y vs, < 60y) 0.74 (0.46–1.19) 0.219   
BMI (≥ 24 kg/m2 vs. < 24 kg/m2) 1.06 (0.66–1.71) 0.808   
Alcohol use 0.71 (0.43–1.19) 0.196   
HBV 1.58 (0.96–2.59) 0.073   
HCV 0.74 (0.46–1.19) 0.212   
Child‐Pugh class A 2.60 (1.19–5.70) 0.017 1.21 (0.46–3.17) 0.697
Cirrhosis 0.52 (0.31–0.88) 0.015 0.90 (0.50–1.60) 0.709
Ascites 0.39 (0.20–0.76) 0.006 0.56 (0.28–1.13) 0.104
Total bilirubin (≥ 1.3 mg/dL vs. < 1.3 mg/dL) 0.33 (0.20–0.54)  < 0.001 0.52 (0.28–0.95) 0.034
Albumin (≥ 3.5 g/dL vs. < 3.5 g/dL) 2.55 (1.33–4.87) 0.005 1.59 (0.74–3.38) 0.232
ALBI grade 1 vs. 2/3 1.91 (1.04–3.52) 0.036 1.10 (0.52–2.35) 0.798
AFP (≥ 200 ng/ml vs. < 200 ng/ml) 0.56 (0.31–1.00) 0.051   
Tumor size (≥ 1.8 cm vs. < 1.8 cm) 0.68 (0.41–1.13) 0.137   
Tumor recurrence 0.45 (0.28–0.74) 0.002 0.46 (0.28–0.78) 0.006
  1. CI: Conference Incidence; SR: Surgical resection; BMI: Body mass index; HBV: Hepatitis B virus; HCV: Hepatitis C virus; ALBI: Albumin- bilirubin; AFP: Alpha-fetoprotein;