Skip to main content

Table 2 Univariable and multivariable Cox‐proportional hazard model for overall survival in BCLC very-early stage hepatocellular carcinoma patients

From: Clinical outcomes of surgical resection versus radiofrequency ablation in very-early‐stage hepatocellular carcinoma: a propensity score matching analysis

Characteristics

Univariate Cox regression analyses

Multivariate Cox regression analyses

Unadjusted HR (95% CI)

P-value

Adjusted HR (95% CI)

P-value

Treatment type (SR vs. RFA)

2.58 (1.56–4.25)

 < 0.001

1.75 (1.08–3.11)

0.046

Male

1.20 (0.71–2.04)

0.501

  

Age (≥ 60y vs, < 60y)

0.74 (0.46–1.19)

0.219

  

BMI (≥ 24 kg/m2 vs. < 24 kg/m2)

1.06 (0.66–1.71)

0.808

  

Alcohol use

0.71 (0.43–1.19)

0.196

  

HBV

1.58 (0.96–2.59)

0.073

  

HCV

0.74 (0.46–1.19)

0.212

  

Child‐Pugh class A

2.60 (1.19–5.70)

0.017

1.21 (0.46–3.17)

0.697

Cirrhosis

0.52 (0.31–0.88)

0.015

0.90 (0.50–1.60)

0.709

Ascites

0.39 (0.20–0.76)

0.006

0.56 (0.28–1.13)

0.104

Total bilirubin (≥ 1.3 mg/dL vs. < 1.3 mg/dL)

0.33 (0.20–0.54)

 < 0.001

0.52 (0.28–0.95)

0.034

Albumin (≥ 3.5 g/dL vs. < 3.5 g/dL)

2.55 (1.33–4.87)

0.005

1.59 (0.74–3.38)

0.232

ALBI grade 1 vs. 2/3

1.91 (1.04–3.52)

0.036

1.10 (0.52–2.35)

0.798

AFP (≥ 200 ng/ml vs. < 200 ng/ml)

0.56 (0.31–1.00)

0.051

  

Tumor size (≥ 1.8 cm vs. < 1.8 cm)

0.68 (0.41–1.13)

0.137

  

Tumor recurrence

0.45 (0.28–0.74)

0.002

0.46 (0.28–0.78)

0.006

  1. CI: Conference Incidence; SR: Surgical resection; BMI: Body mass index; HBV: Hepatitis B virus; HCV: Hepatitis C virus; ALBI: Albumin- bilirubin; AFP: Alpha-fetoprotein;