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Table 1 Clinical characteristics of BCLC very-early stage hepatocellular carcinoma patients before and after propensity scores matching

From: Clinical outcomes of surgical resection versus radiofrequency ablation in very-early‐stage hepatocellular carcinoma: a propensity score matching analysis

Characteristics Study population before PSM Study population after PSM
Total SR group RFA group P-value Total SR group RFA group P-value
Patients 188 103 85   116 58 58  
Age, years 59 (23–82) 57 (23–82) 62 (34–81) 0.006 61 (34–82) 61 (35–82) 61 (34–80) 0.788
Sex         
Male 130(69.1) 75 (72.8) 55 (64.7) 0.299 78 (67.2) 39 (67.2) 39 (67.2) 1
Female 58 (30.9) 28 (27.2) 30 (35.3)   38 (32.8) 19 (32.8) 19 (32.8)  
BMI         
24 kg/m2 93 (49.5) 50 (48.5) 43 (50.6) 0.895 59 (50.9) 29 (50.0) 30 (51.7) 1
 > 24 kg/m2 95 (50.5) 53 (51.5) 42 (49.4)   57 (49.1) 29 (50.0) 28 (48.3)  
Alcohol use 53 (28.2) 25 (24.33) 28 (32.9) 0.249 32 (27.6) 15 (25.9) 17 (29.3) 0.835
HBV         
Positive 86 (45.7) 51 (49.5) 35 (41.2) 0.320 51 (44.0) 28 (48.3) 23 (39.7) 0.454
Negative 102 (54.3) 52 (50.5) 50 (58.8)   65 (56.0) 30 (51.7) 35 (60.3)  
HCV         
Positive 91(48.4) 49 (47.6) 42 (49.4) 0.917 61 (52.6) 34 (58.6) 27 (46.6) 0.265
Negative 97 (51.6) 54 (52.4) 43 (50.6)   55 (47.4) 24 (41.4) 31 (53.4)  
Child‐Pugh class A 179 (95.2) 100 (97.1) 79 (92.9) 0.326 113 (97.4) 56 (96.6) 57(98.3) 1
Cirrhosis 115 (61.2) 54 (52.4) 61 (71.8) 0.011 72 (62.1) 36 (62.1) 36 (62.1) 1
Ascites 13 (6.9) 6 (5.8) 7 (8.2) 0.719 8 (6.9) 4 (6.9) 4 (6.9) 1
INR 1.0 (0.9–1.7) 1.0 (0.9–1.3) 1.1 (0.9–1.7)  < 0.001 1.0 (0.9–1.7) 1.0 (0.9–1.3) 1.0 (0.9–1.7) 0.382
Total bilirubin, mg/dL 0.9 (0.2–5.4) 0.8 (0.2–5.4) 1.1 (0.3–4.2) 0.001 1.0 (0.3–3.9) 0.8 (0.5–3.9) 1.1 (0.3–4.2) 0.785
Albumin, g/dL 4.1 (2.5–4.9) 4.2 (3.2–4.9) 4.0 (2.5–4.7)  < 0.001 4.1 (2.6–4.9) 4.1 (3.2–4.9) 4.0 (2.6–4.6) 0.051
ALBI grade 1 166 (88.3) 97 (94.2) 69 (81.2) 0.011 102 (87.9) 53 (91.4) 49 (84.5) 0.393
AFP > 200 ng/ml 29 (15.4) 12 (11.7) 17 (20.0) 0.169 17 (14.7) 5 (8.6) 12 (20.7) 0.115
Tumor size, cm 1.8 (1.0–2.0) 1.8 (1.0–2.0) 1.8 (1.0–2.0) 0.127 1.8(1.0–2.0) 1.9 (1.0–2.0) 1.8 (1.0–2.0) 0.875
Mortality 69 (36.7) 28 (27.2) 41 (48.2) 0.005 44 (37.9) 17 (29.3) 27 (46.6) 0.085
Recurrence 79 (42.0) 43 (41.7) 36 (42.4) 1.000 49 (42.2) 25 (43.1) 24 (41.4) 1.000
  1. Data shown as median (range) or number (%); PSM: propensity score matching; SR: Surgical resection; RFA: Radiofrequency ablation; BMI: Body mass index; HBV: Hepatitis B virus; HCV: Hepatitis C virus; INR: international normalized ratio; ALBI: Albumin- bilirubin; AFP: Alpha-fetoprotein;