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Table 3 Relationships between androgen level and severity scores in hepatitis B virus-related acute-on-chronic liver failure

From: Lower testosterone levels predict increasing severity and worse outcomes of hepatitis B virus-related acute-on-chronic liver failure in males

  Estimate (95% CI) P value
MELD
1–Ln (total testosterone [ng/dL]) 2.794 (1.740–3.848)  < 0.001
1–Ln (sex-hormone-binding globulin [nmol/L]) 4.621 (2.727–6.515)  < 0.001
1–Ln (free testosterone index [%]) 2.107 (0.703–3.512) 0.004
SQRT (dehydroepiandrosterone sulfate [μg/dL]) 0.324 (0.145–0.503)  < 0.001
SQRT (cortisol [μg/dL]) 1.717 (0.975–2.459)  < 0.001
SQRT (androstenedione [ng/mL]) 4.982 (3.304–6.660)  < 0.001
COSSH-ACLF
1–Ln (total testosterone [ng/dL]) 0.527 (0346–0.708)  < 0.001
1–Ln (sex-hormone-binding globulin [nmol/L]) 1.033 (0.720–1.347)  < 0.001
1–Ln (free testosterone index [%]) 0.318 (0.071–0.565) 0.012
SQRT (dehydroepiandrosterone sulfate [μg/dL]) 0.048 (0.034–0.062)  < 0.001
SQRT (cortisol [μg/dL]) 0.234 (0.103–0.364) 0.001
SQRT (androstenedione [ng/mL]) 0.790 (0.492–1.089)  < 0.001
  1. MELD Model for End-stage Liver Disease, COSSH-ACLF Chinese Group on the Study of Severe Hepatitis B-acute-on-chronic liver failure, SQRT Square Root
  2. Multiple linear regression analysis adjusted for age and body mass index. Estimates (slopes) are given with 95% confidence intervals within parentheses