Table 2 Meta-analysis of the clinicopathological significance of HSP70 expression in patients with gastric cancer
Clinicopathological features | Reference count | Heterogeneity (I-squared, p) | Model | OR with 95% CI | P value | Conclusion |
|---|---|---|---|---|---|---|
Age (≤ 60 years vs > 60) | 2 | 0.0%, 0.458 | Fixed | 1.07(0.61–1.87) | 0.809 | Not significant |
Gender (male vs female) | 8 | 1.0%,0.421 | Fixed | 1.18(0.91–1.53) | 0.217 | Not significant |
Depth of invasion (T3/T4 vs T1/T2) | 7 | 80.9%, < 0.001 | Random | 1.01(0.45–2.30) | 0.975 | Not significant |
Differentiation degrees (low vs high) | 5 | 0.0%, 0. 479 | Fixed | 0.49(0.37–0.65) |  < 0.001 | Significant |
H.pylori infection (positive vs negative) | 2 | 48.3%, 0.164 | Fixed | 2.04(0.82–5.03) | 0.123 | Not significant |
Histological subtypes (intestinal vs diffuse) | 4 | 43.0%, 0.153 | Fixed | 2.19(1.59–3.01) |  < 0.001 | Significant |
Lymph node invasion (positive vs negative) | 9 | 74.2%, < 0.001 | Random | 1.28(0.72–2.30) | 0.399 | Not significant |
TNM stages (I/II vs III/IV) | 6 | 74.2%, 0.002 | Random | 1.15(0.60–2.24) | 0.672 | Not significant |
Lymphovascular invasion (positive vs negative) | 5 | 22.9%,0.268 | Fixed | 1.54(1.19–2.00) | 0.001 | Significant |
Metastasis (positive vs negative) | 5 | 59.4%,0.043 | Random | 1.61(0.50–5.25) | 0.426 | Not significant |