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Table 2 Meta-analysis of the clinicopathological significance of HSP70 expression in patients with gastric cancer

From: Clinicopathological significance of HSP70 expression in gastric cancer: a systematic review and meta-analysis

Clinicopathological features Reference count Heterogeneity (I-squared, p) Model OR with 95% CI P value Conclusion
Age (≤ 60 years vs > 60) 2 0.0%, 0.458 Fixed 1.07(0.61–1.87) 0.809 Not significant
Gender (male vs female) 8 1.0%,0.421 Fixed 1.18(0.91–1.53) 0.217 Not significant
Depth of invasion (T3/T4 vs T1/T2) 7 80.9%, < 0.001 Random 1.01(0.45–2.30) 0.975 Not significant
Differentiation degrees (low vs high) 5 0.0%, 0. 479 Fixed 0.49(0.37–0.65)  < 0.001 Significant
H.pylori infection (positive vs negative) 2 48.3%, 0.164 Fixed 2.04(0.82–5.03) 0.123 Not significant
Histological subtypes (intestinal vs diffuse) 4 43.0%, 0.153 Fixed 2.19(1.59–3.01)  < 0.001 Significant
Lymph node invasion (positive vs negative) 9 74.2%, < 0.001 Random 1.28(0.72–2.30) 0.399 Not significant
TNM stages (I/II vs III/IV) 6 74.2%, 0.002 Random 1.15(0.60–2.24) 0.672 Not significant
Lymphovascular invasion (positive vs negative) 5 22.9%,0.268 Fixed 1.54(1.19–2.00) 0.001 Significant
Metastasis (positive vs negative) 5 59.4%,0.043 Random 1.61(0.50–5.25) 0.426 Not significant
  1. HSP70 heat shock protein 70; OR odds ratio; CI confidence interval