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Table 10 The list of amino acid residues involved in the interactions between NS5A, NS5B, and HCV inhibitors

From: First report on molecular docking analysis and drug resistance substitutions to approved HCV NS5A and NS5B inhibitors amongst Iranian patients

Proteins

HCV inhibitors

Daclatasvir

Elbasvir

Ledipasvir

Ombitasvir

Dasabuvir

Sofosbuvir

NS5A 1a

TRP9

PRO35

PHE36

ARG78

TRP84

GLU181

TYR129

SER186

GLY185

PRO192

GLU193

TYR129

THR210

THR213

ALA214

HIS150

TYR182

GLN187

TYR129

PRO194

PHE127

ARG204

  

NS5A 1a

(Mutant GLU181)

–

GLU327

ASP292

–

–

  

NS5A 3a

TRP9

PRO35

PHE36

ARG78

TRP84

GLU181

TYR129

SER186

GLY185

PRO192

GLU193

TYR129

ARG122

THR210

THR213

ALA214

HIS150

TYR182

GLN187

TYR129

PRO194

PHE127

ARG204

  

NS5B 1a

    

GLU202

ARG591

ARG465

LEU545

LEU547

HIS467

GLY468

ARG591

ARG465

LEU547

NS5B 3a

    

MET217

LYS216

ARG213

PRO199

GLU212

GLN209

TYR205

ALA26

ARG411

HIS412

PRO414

HIS105

PRO104