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Table 10 The list of amino acid residues involved in the interactions between NS5A, NS5B, and HCV inhibitors

From: First report on molecular docking analysis and drug resistance substitutions to approved HCV NS5A and NS5B inhibitors amongst Iranian patients

Proteins HCV inhibitors
Daclatasvir Elbasvir Ledipasvir Ombitasvir Dasabuvir Sofosbuvir
NS5A 1a TRP9
PRO35
PHE36
ARG78
TRP84
GLU181
TYR129
SER186
GLY185
PRO192
GLU193
TYR129
THR210
THR213
ALA214
HIS150
TYR182
GLN187
TYR129
PRO194
PHE127
ARG204
  
NS5A 1a
(Mutant GLU181)
GLU327
ASP292
  
NS5A 3a TRP9
PRO35
PHE36
ARG78
TRP84
GLU181
TYR129
SER186
GLY185
PRO192
GLU193
TYR129
ARG122
THR210
THR213
ALA214
HIS150
TYR182
GLN187
TYR129
PRO194
PHE127
ARG204
  
NS5B 1a      GLU202
ARG591
ARG465
LEU545
LEU547
HIS467
GLY468
ARG591
ARG465
LEU547
NS5B 3a      MET217
LYS216
ARG213
PRO199
GLU212
GLN209
TYR205
ALA26
ARG411
HIS412
PRO414
HIS105
PRO104