Proteins | HCV inhibitors | |||||
---|---|---|---|---|---|---|
Daclatasvir | Elbasvir | Ledipasvir | Ombitasvir | Dasabuvir | Sofosbuvir | |
NS5A 1a | TRP9 PRO35 PHE36 ARG78 TRP84 | GLU181 TYR129 SER186 GLY185 | PRO192 GLU193 TYR129 THR210 THR213 ALA214 | HIS150 TYR182 GLN187 TYR129 PRO194 PHE127 ARG204 | Â | Â |
NS5A 1a (Mutant GLU181) | – | GLU327 ASP292 | – | – |  |  |
NS5A 3a | TRP9 PRO35 PHE36 ARG78 TRP84 | GLU181 TYR129 SER186 GLY185 | PRO192 GLU193 TYR129 ARG122 THR210 THR213 ALA214 | HIS150 TYR182 GLN187 TYR129 PRO194 PHE127 ARG204 | Â | Â |
NS5B 1a | Â | Â | Â | Â | GLU202 ARG591 ARG465 LEU545 LEU547 | HIS467 GLY468 ARG591 ARG465 LEU547 |
NS5B 3a | Â | Â | Â | Â | MET217 LYS216 ARG213 PRO199 GLU212 GLN209 TYR205 | ALA26 ARG411 HIS412 PRO414 HIS105 PRO104 |