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Table 1 Comparison of clinicopathological characteristics between sAFP-N vs. sAFP-H and between nGAPEP vs. GAPEP in the surgical cases (group A)

From: Both the serum AFP test and AFP/GPC3/SALL4 immunohistochemistry are beneficial for predicting the prognosis of gastric adenocarcinoma

  sAFP-N sAFP-H P nGAPEP GAPEP P
Age  ≤ 50 93 (23.02%) 8 (47.06%) 0.023 91 (23.51%) 10 (29.41%) 0.440
 > 50 311 (76.98%) 9 (52.94%)   296 (76.49%) 24 (70.59%)  
Sex Male 272 (67.33%) 12 (70.59%) 0.779 259 (66.93%) 25 (73.53%) 0.431
Female 132 (32.67%) 5 (29.31%)   128 (33.07%) 9 (26.47%)  
Location* Proximal 64 (16.04%) 2 (11.76%) 0.164 60 (15.67%) 6 (18.18%) 0.359
Distal 275 (68.92%) 15 (88.24%)   265 (69.19%) 25 (75.76%)  
Overlapping 60 (15.04%) 0 (0.00%)   58 (15.14%) 2 (6.06%)  
Lauren classification Intestinal 88 (21.78%) 8 (47.06%) 0.030 83 (21.45%) 13 (38.24%) 0.081
Diffuse 262 (64.85%) 6 (35.29%)   251 (64.86%) 17 (50.00%)  
Mixed 54 (13.37%) 3 (17.65%)   53 (13.69%) 4 (11.76%)  
Histological classification** Tub1 10 (2.48%) 0 (0.00%) 0.021 10 (2.58%) 0 (0%) 0.009
Tub2 72 (17.82%) 8 (47.06%)   68 (17.57%) 12 (35.29%)  
Muc 6 (1.49%) 0 (0.00%)   5 (1.29%) 1 (2.94%)  
Sig 139 (34.41%) 0 (0.00%)   137 (35.40%) 2 (5.88%)  
Por1 62 (15.35%) 4 (23.53%)   58 (14.99%) 8 (23.53%)  
Por2 61 (15.10%) 2 (11.76%)   56 (14.47%) 7 (20.59%)  
Others 54 (13.37%) 3 (17.65%)   53 (13.70%) 4 (11.76%)  
T category T1 142 (35.15%) 0 (0.00%) 0.014 140 (36.18%) 2 (5.88%) 0.001
T2 57 (14.11%) 5 (29.41%)   52 (13.44%) 10 (29.41%)  
T3 55 (13.61%) 2 (11.76%)   54 (13.95%) 3 (8.82%)  
T4 150 (37.13%) 10 (58.82%)   141 (36.43%) 19 (55.88%)  
N category N0 150 (40.00%) 3 (17.65%) 0.047 141 (39.39%) 12 (35.29%) 0.152
N1 63 (16.80%) 1 (5.88%)   62 (17.32%) 2 (5.88%)  
N2 51 (13.60%) 4 (23.53%)   47 (13.13%) 8 (23.53%)  
N3 111 (29.60%) 9 (52.94%)   108 (30.17%) 12 (35.29%)  
LVI No 262 (64.85%) 4 (23.53%) 0.001 249 (64.34%) 17 (50.00%) 0.096
Yes 142 (35.15%) 13 (76.47%)   138 (35.66%) 17 (50.00%)  
PNS No 269 (66.58%) 6 (35.29%) 0.008 257 (66.41%) 18 (52.94%) 0.114
Yes 135 (33.42%) 11 (64.71%)   130 (33.59%) 16 (47.06%)  
Postoperative recurrence/metastasis No 200 (94.34%) 13 (76.47%) < 0.001 379 (97.93%) 26 (76.47%) < 0.001
Yes 12 (5.66%) 4 (23.53%)   8 (2.07%) 8 (23.53%)  
  1. LVI, lymphovascular invasion; PNS, perineural spread
  2. *Proximal = tumor in upper 1/2 with a proximal gastrectomy; dismal = tumor in lower 1/2 with a dismal gastrectomy; overlapping = large tumor or linitis plastica with a total gastrectomy
  3. **Based on the Japanese Gastric Cancer Association classification, tub1 = well differentiated tubular type, tub2 = moderately differentiated tubular type, por1 = solid type, por2 = poorly cohesive type, sig = signet-ring cell type, muc = mucin type, and other types