| |
sAFP-N
|
sAFP-H
|
P
|
nGAPEP
|
GAPEP
|
P
|
|---|
|
Age
|
≤ 50
|
93 (23.02%)
|
8 (47.06%)
|
0.023
|
91 (23.51%)
|
10 (29.41%)
|
0.440
|
|
> 50
|
311 (76.98%)
|
9 (52.94%)
| |
296 (76.49%)
|
24 (70.59%)
| |
|
Sex
|
Male
|
272 (67.33%)
|
12 (70.59%)
|
0.779
|
259 (66.93%)
|
25 (73.53%)
|
0.431
|
|
Female
|
132 (32.67%)
|
5 (29.31%)
| |
128 (33.07%)
|
9 (26.47%)
| |
|
Location*
|
Proximal
|
64 (16.04%)
|
2 (11.76%)
|
0.164
|
60 (15.67%)
|
6 (18.18%)
|
0.359
|
|
Distal
|
275 (68.92%)
|
15 (88.24%)
| |
265 (69.19%)
|
25 (75.76%)
| |
|
Overlapping
|
60 (15.04%)
|
0 (0.00%)
| |
58 (15.14%)
|
2 (6.06%)
| |
|
Lauren classification
|
Intestinal
|
88 (21.78%)
|
8 (47.06%)
|
0.030
|
83 (21.45%)
|
13 (38.24%)
|
0.081
|
|
Diffuse
|
262 (64.85%)
|
6 (35.29%)
| |
251 (64.86%)
|
17 (50.00%)
| |
|
Mixed
|
54 (13.37%)
|
3 (17.65%)
| |
53 (13.69%)
|
4 (11.76%)
| |
|
Histological classification**
|
Tub1
|
10 (2.48%)
|
0 (0.00%)
|
0.021
|
10 (2.58%)
|
0 (0%)
|
0.009
|
|
Tub2
|
72 (17.82%)
|
8 (47.06%)
| |
68 (17.57%)
|
12 (35.29%)
| |
|
Muc
|
6 (1.49%)
|
0 (0.00%)
| |
5 (1.29%)
|
1 (2.94%)
| |
|
Sig
|
139 (34.41%)
|
0 (0.00%)
| |
137 (35.40%)
|
2 (5.88%)
| |
|
Por1
|
62 (15.35%)
|
4 (23.53%)
| |
58 (14.99%)
|
8 (23.53%)
| |
|
Por2
|
61 (15.10%)
|
2 (11.76%)
| |
56 (14.47%)
|
7 (20.59%)
| |
|
Others
|
54 (13.37%)
|
3 (17.65%)
| |
53 (13.70%)
|
4 (11.76%)
| |
|
T category
|
T1
|
142 (35.15%)
|
0 (0.00%)
|
0.014
|
140 (36.18%)
|
2 (5.88%)
|
0.001
|
|
T2
|
57 (14.11%)
|
5 (29.41%)
| |
52 (13.44%)
|
10 (29.41%)
| |
|
T3
|
55 (13.61%)
|
2 (11.76%)
| |
54 (13.95%)
|
3 (8.82%)
| |
|
T4
|
150 (37.13%)
|
10 (58.82%)
| |
141 (36.43%)
|
19 (55.88%)
| |
|
N category
|
N0
|
150 (40.00%)
|
3 (17.65%)
|
0.047
|
141 (39.39%)
|
12 (35.29%)
|
0.152
|
|
N1
|
63 (16.80%)
|
1 (5.88%)
| |
62 (17.32%)
|
2 (5.88%)
| |
|
N2
|
51 (13.60%)
|
4 (23.53%)
| |
47 (13.13%)
|
8 (23.53%)
| |
|
N3
|
111 (29.60%)
|
9 (52.94%)
| |
108 (30.17%)
|
12 (35.29%)
| |
|
LVI
|
No
|
262 (64.85%)
|
4 (23.53%)
|
0.001
|
249 (64.34%)
|
17 (50.00%)
|
0.096
|
|
Yes
|
142 (35.15%)
|
13 (76.47%)
| |
138 (35.66%)
|
17 (50.00%)
| |
|
PNS
|
No
|
269 (66.58%)
|
6 (35.29%)
|
0.008
|
257 (66.41%)
|
18 (52.94%)
|
0.114
|
|
Yes
|
135 (33.42%)
|
11 (64.71%)
| |
130 (33.59%)
|
16 (47.06%)
| |
|
Postoperative recurrence/metastasis
|
No
|
200 (94.34%)
|
13 (76.47%)
|
< 0.001
|
379 (97.93%)
|
26 (76.47%)
|
< 0.001
|
|
Yes
|
12 (5.66%)
|
4 (23.53%)
| |
8 (2.07%)
|
8 (23.53%)
| |
- LVI, lymphovascular invasion; PNS, perineural spread
- *Proximal = tumor in upper 1/2 with a proximal gastrectomy; dismal = tumor in lower 1/2 with a dismal gastrectomy; overlapping = large tumor or linitis plastica with a total gastrectomy
- **Based on the Japanese Gastric Cancer Association classification, tub1 = well differentiated tubular type, tub2 = moderately differentiated tubular type, por1 = solid type, por2 = poorly cohesive type, sig = signet-ring cell type, muc = mucin type, and other types
