Immune cell
|
Gene markers
|
Tumor
|
Tumor-sum
|
Normal
|
Tumor-sum
|
---|
Cor
|
P value
|
Cor
|
P value
|
Cor
|
P value
|
Cor
|
P value
|
---|
CD8+ T cell
|
CD8A
|
0.2
|
**
|
0.2
|
**
|
0.39
|
*
|
0.37
|
*
|
|
CD8B
|
0.23
|
***
| | |
0.31
|
0.026
| | |
T cell
|
CD6
|
0.12
|
0.024
|
0.2
|
**
|
0.24
|
0.093
|
0.41
|
*
|
|
CD3D
|
0.23
|
***
| | |
0.42
|
*
| | |
|
CD3E
|
0.13
|
*
| | |
0.34
|
0.017
| | |
|
SH2D1A
|
0.13
|
0.014
| | |
0.39
|
*
| | |
|
TRAT1
|
0.049
|
0.35
| | |
0.36
|
*
| | |
|
CD3G
|
0.24
|
***
| | |
0.35
|
0.013
| | |
|
CD2
|
0.15
|
*
| | |
0.3
|
0.035
| | |
B cell
|
CD19
|
0.096
|
0.066
|
0.17
|
*
|
0.28
|
0.051
|
0.44
|
*
|
|
FCRL2
|
0.068
|
0.19
| | |
0.5
|
**
| | |
|
KIAA0125
|
0.052
|
0.32
| | |
0.52
|
**
| | |
|
TNFRSF17
|
0.06
|
0.25
| | |
0.43
|
*
| | |
|
SPIB
|
0.13
|
0.01
| | |
0.22
|
0.12
| | |
|
PNOC
|
0.071
|
0.18
| | |
0.48
|
**
| | |
|
CD79A
|
0.062
|
0.24
| | |
0.38
|
*
| | |
Monocyte
|
CD86
|
0.32
|
***
|
0.28
|
***
|
0.21
|
0.15
|
0.28
|
0.052
|
|
CD115(CSF1R)
|
0.25
|
***
| | |
0.27
|
0.056
| | |
TAM
|
CD68
|
0.26
|
***
|
0.27
|
***
|
0.2
|
0.15
|
0.21
|
0.14
|
|
IL10
|
0.21
|
***
| | |
0.15
|
0.29
| | |
M1 Macrophage
|
IRF5
|
0.31
|
***
|
0.31
|
***
|
0.13
|
0.37
|
0.07
|
0.63
|
|
COX2(PTGS2)
|
0.078
|
0.14
| | |
− 0.032
|
0.82
| | |
M2 Macrophage
|
CD163
|
0.15
|
*
|
0.12
|
0.018
|
0.18
|
0.22
|
0.25
|
0.078
|
|
MS4A4A
|
0.16
|
*
| | |
0.22
|
0.12
| | |
Neutrophils
|
FPR1
|
0.25
|
***
|
0.37
|
***
|
− 0.035
|
0.81
|
0.15
|
0.3
|
|
SIGLEC5
|
0.31
|
***
| | |
− 0.011
|
0.94
| | |
|
CSF3R
|
0.22
|
***
| | |
0.11
|
0.43
| | |
|
FCGR3B
|
0.05
|
0.34
| | |
0.17
|
0.24
| | |
|
CEACAM3
|
0.19
|
**
| | |
0.064
|
0.66
| | |
|
CD116(ITGAM)
|
0.33
|
***
| | |
0.36
|
0.011
| | |
CD8+ T cell
|
CD8A
|
0.2
|
**
|
0.2
|
**
|
0.39
|
*
|
0.37
|
*
|
|
CD8B
|
0.23
|
***
| | |
0.31
|
0.026
| | |
T cell
|
CD6
|
0.12
|
0.024
|
0.2
|
**
|
0.24
|
0.093
|
0.41
|
*
|
|
CD3D
|
0.23
|
***
| | |
0.42
|
*
| | |
|
CD3E
|
0.13
|
*
| | |
0.34
|
0.017
| | |
|
SH2D1A
|
0.13
|
0.014
| | |
0.39
|
*
| | |
|
TRAT1
|
0.049
|
0.35
| | |
0.36
|
*
| | |
|
CD3G
|
0.24
|
***
| | |
0.35
|
0.013
| | |
|
CD2
|
0.15
|
*
| | |
0.3
|
0.035
| | |
B cell
|
CD19
|
0.096
|
0.066
|
0.17
|
*
|
0.28
|
0.051
|
0.44
|
*
|
|
FCRL2
|
0.068
|
0.19
| | |
0.5
|
**
| | |
|
KIAA0125
|
0.052
|
0.32
| | |
0.52
|
**
| | |
|
TNFRSF17
|
0.06
|
0.25
| | |
0.43
|
*
| | |
|
SPIB
|
0.13
|
0.01
| | |
0.22
|
0.12
| | |
|
PNOC
|
0.071
|
0.18
| | |
0.48
|
**
| | |
|
CD79A
|
0.062
|
0.24
| | |
0.38
|
*
| | |
Monocyte
|
CD86
|
0.32
|
***
|
0.28
|
***
|
0.21
|
0.15
|
0.28
|
0.052
|
|
CD115(CSF1R)
|
0.25
|
***
| | |
0.27
|
0.056
| | |
TAM
|
CD68
|
0.26
|
***
|
0.27
|
***
|
0.2
|
0.15
|
0.21
|
0.14
|
|
IL10
|
0.21
|
***
| | |
0.15
|
0.29
| | |
M1 Macrophage
|
IRF5
|
0.31
|
***
|
0.31
|
***
|
0.13
|
0.37
|
0.07
|
0.63
|
|
COX2(PTGS2)
|
0.078
|
0.14
| | |
− 0.032
|
0.82
| | |
M2 Macrophage
|
CD163
|
0.15
|
*
|
0.12
|
0.018
|
0.18
|
0.22
|
0.25
|
0.078
|
|
MS4A4A
|
0.16
|
*
| | |
0.22
|
0.12
| | |
Neutrophils
|
FPR1
|
0.25
|
***
|
0.37
|
***
|
− 0.035
|
0.81
|
0.15
|
0.3
|
|
SIGLEC5
|
0.31
|
***
| | |
− 0.011
|
0.94
| | |
|
CSF3R
|
0.22
|
***
| | |
0.11
|
0.43
| | |
|
FCGR3B
|
0.05
|
0.34
| | |
0.17
|
0.24
| | |
|
CEACAM3
|
0.19
|
**
| | |
0.064
|
0.66
| | |
|
CD116(ITGAM)
|
0.33
|
***
| | |
0.36
|
0.011
| | |
Central memory T cell
|
CCR7
|
0.063
|
0.23
|
0.12
|
0.023
|
0.37
|
*
|
0.38
|
*
|
|
SELL
|
0.1
|
0.055
| | |
0.24
|
0.092
| | |
|
IL7R
|
0.042
|
0.43
| | |
0.31
|
0.031
| | |
Resident memory T cell
|
CD69
|
0.063
|
0.23
|
0.28
|
***
|
0.3
|
0.037
|
0.25
|
0.075
|
|
ITGAE
|
0.21
|
***
| | |
− 0.046
|
0.75
| | |
|
CXCR6
|
0.12
|
0.02
| | |
0.25
|
0.085
| | |
|
MYADM
|
0.27
|
***
| | |
− 0.092
|
0.52
| | |
Exhausted T cell
|
TIM-3(HAVCR2)
|
0.14
|
*
|
0.3
|
***
|
0.15
|
0.31
|
0.37
|
*
|
|
PD-1 (PDCD1)
|
0.15
|
*
| | |
0.46
|
**
| | |
|
TIGIT
|
0.21
|
***
| | |
0.34
|
0.015
| | |
|
LAG3
|
0.16
|
*
| | |
0.15
|
0.31
| | |
|
CXCL13
|
0.085
|
0.1
| | |
0.28
|
0.049
| | |
|
LAYN
|
0.12
|
0.024
| | |
0.26
|
0.073
| | |
Resting Treg T cell
|
FOXP3
|
0.011
|
0.84
|
0.18
|
**
|
0.29
|
0.038
|
0.47
|
**
|
|
IL2RA
|
0.2
|
***
| | |
0.18
|
0.21
| | |
Effector Treg T cell
|
CTLA4
|
0.21
|
***
|
0.27
|
***
|
0.36
|
*
|
0.4
|
*
|
|
CCR8
|
0.23
|
***
| | |
0.37
|
*
| | |
|
TNFRSF9
|
0.018
|
0.74
| | |
0.36
|
*
| | |
- Cor, ρ value of Spearman's correlation. Tumor, single gene marker correlation analysis in LIHC tissue. Normal, single gene marker correlation analysis in normal tissue; Cor, ρ-value upon Spearman correlation. Significance levels: *P < 0.05; **P < 0.01; ***P < 0.001