|
Gastrointestinal disorders (n, %)
| | | | | | | | |
|
Diarrhea
|
3 (100)
|
0
|
16 (64.0)
|
1 (4.0)
|
36 (67.9)
|
1 (1.9)
|
55 (67.9)
|
2 (2.5)
|
|
Oral ulcer
|
0
|
0
|
4 (16.0)
|
0
|
21 (39.6)
|
1 (1.9)
|
25 (30.9)
|
1 (1.2)
|
|
Vomiting
|
1 (33.3)
|
0
|
8 (32.0)
|
1 (4.0)
|
11 (20.8)
|
0
|
20 (24.7)
|
1 (1.2)
|
|
Nausea
|
1 (33.3)
|
0
|
8 (32.0)
|
1 (4.0)
|
7 (13.2)
|
1 (1.9)
|
16 (19.8)
|
2 (2.5)
|
|
Oral mucositis
|
0
|
0
|
3 (12.0)
|
0
|
7 (13.2)
|
0
|
10 (12.3)
|
0
|
|
Skin and subcutaneous tissue disorders (n, %)
| | | | | | | | |
|
Rash
|
1 (33.3)
|
0
|
10 (40.0)
|
0
|
41 (77.4)
|
7 (13.2)
|
52 (64.2)
|
7 (8.6)
|
|
Palmar-plantar erythrodysesthesia syndrome
|
1 (33.3)
|
1 (33.3)
|
7 (28.0)
|
1 (4.0)
|
24 (45.3)
|
2 (3.8)
|
32 (39.5)
|
4 (4.9)
|
|
Investigations (n, %)
| | | | | | | | |
|
Elevated AST
|
0
|
0
|
4 (16.0)
|
0
|
17 (32.1)
|
4 (7.5)
|
21 (25.9)
|
4 (4.9)
|
|
Elevated ALT
|
0
|
0
|
5 (20.0)
|
0
|
15 (28.3)
|
2 (3.8)
|
20 (24.7)
|
2 (2.5)
|
|
Leukopenia
|
0
|
0
|
3 (12.0)
|
0
|
6 (11.3)
|
0
|
9 (11.1)
|
0
|
|
Metabolism and nutrition disorders (n, %)
| | | | | | | | |
|
Anorexia
|
0
|
0
|
2 (8.0)
|
0
|
10 (18.9)
|
1 (1.9)
|
12 (14.8)
|
1 (1.2)
|
|
Hypoalbuminemia
|
0
|
0
|
0
|
0
|
12 (22.6)
|
0
|
12 (14.8)
|
0
|
|
Infections and infestations (n, %)
| | | | | | | | |
|
Paronychia
|
0
|
0
|
4 (16.0)
|
0
|
7 (13.2)
|
1 (1.9)
|
11 (13.6)
|
1 (1.2)
|
|
General disorders and administration site conditions (n, %)
| | | | | | | | |
|
Fatigue
|
0
|
0
|
3 (12.0)
|
1 (4.0)
|
9 (17.0)
|
2 (3.8)
|
12 (14.8)
|
3 (3.7)
|
|
Blood and lymphatic system disorders (n, %)
| | | | | | | | |
|
Anemia
|
1 (33.3)
|
1 (33.3)
|
4 (16.0)
|
1 (4.0)
|
20 (37.7)
|
3 (5.7)
|
25 (30.9)
|
5 (6.2)
|
|
Renal and urinary disorders (n, %)
| | | | | | | | |
|
Proteinuria
|
0
|
0
|
3 (12.0)
|
0
|
13 (24.5)
|
0
|
16 (19.8)
|
0
|
