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Table 2 Clinical advantages of probiotics in animal studies

From: Probiotics as the live microscopic fighters against Helicobacter pylori gastric infections

Fist author Year Probiotic strain name Dosage /duration Animal model Conclusion remarks Ref
Ushiyama et al 2003 L. gasseri OLL2716 107 CFU/mL BALB/c mice Anti-H. pylori effects
Reduction of IL-8
[122]
Sgouras et al 2004 L. casei Shirota 108 CFU/mL, 9 months C57BL/6 mice Reducing H. pylori colonization and decrease specific IgG titer [69]
Henry et al 2004 L. rhamnosus R0011, L. acidophilus R0052 109 CFU/mL, 9 weeks C57BL/6 mice Anti-H. pylori effects
Reduce gastric inflammation
[71]
Pena et al 2005 L. reuteri 1602, L. paracasei 6798 109 CFU/mL, 12 weeks C57BL/6 mice Reducing the TNF-α and IL-12 levels [123]
Sgouras et al 2005 L. johnsonii La1
L. amylovorus CDE471
L. acidophilus IBB 801
1.5–4 × 108 CFU/mL, 3 months C57BL/6 mice Reducing H. pylori colonization and decrease gastric inflammation [137]
Brzozowski et al 2006 L. acidophilus R0052
L. rhamnosus R0011
2 × 109 CFU/mL, 2 weeks Mongolian gerbil Reduction gastrin and gastric inflammation [138]
Chenoll et al 2011 B. bifidum CECT 7366 109 CFU/mL C57BL/6 mice Blocking colonization of H. pylori [139]
Kuo et al 2013 L. acidophilus, B. lactis 5 × 109 CFU/mL Mongolian gerbil Reduction of gastric inflammation [140]
Kaur et al 2014 P. acidilactici BA28 109 CFU/mL, 24 weeks C57BL/6 mice Anti-H. pylori [141]
Kim et al 2014 P. pentosaseus (SL4) 108 CFU/mL, 6 weeks C57BL/6 mice Anti-H. pylori [142]
Zaman et al 2014 L. reuteri
L. johnsonii
L. murinus
109 CFU/mL Mongolian gerbil Anti-H. pylori [143]
Matsui et al 2015 L. gasseri SBT2055 109 CFU/mL C57BL/6 mice Production of specific IgA, Blocking progression of MALT [144]
Yu et al 2015 E. faecalis
B. longum
L. acidophilus
107 CFU/mL C57BL/6 mice Reducing gastric inflammation [145]
Pan et al 2016 L. plantarum ZDY 2013 109 CFU/mL C57BL/6 mice Reducing gastric inflammation [146]
Afsahi et al 2018 L. plantarum ATCC8014 106 CFU/mL, 2 weeks C57BL/6 mice Anti-H. pylori
Reduction of gastric inflammation
[147]
Chen et al 2018 L. rhamnosus JB3 5 × 107 CFU/mL C57BL/6 mice Anti-H. pylori
Reduction of gastric inflammation
[148]
Merino et al 2018 L. fermentum UCO-979C 107 CFU/mL Mongolian gerbil Inhibited H. pylori SS1 [149]
Lin et al 2020 L. fermentum P2 (P2), L. casei L21 (L21), L. rhamnosus JB3 (JB3) 107 CFU/mL C57BL/6 mice Reduction of gastric inflammation [150]