Probiotics as the live microscopic fighters against Helicobacter pylori gastric infections

Keikha, Masoud; Karbalaei, Mohsen

doi:10.1186/s12876-021-01977-1

BMC Gastroenterology

Table 2 Clinical advantages of probiotics in animal studies

From: Probiotics as the live microscopic fighters against Helicobacter pylori gastric infections

Fist author	Year	Probiotic strain name	Dosage /duration	Animal model	Conclusion remarks	Ref
Ushiyama et al	2003	L. gasseri OLL2716	10⁷ CFU/mL	BALB/c mice	Anti-H. pylori effects Reduction of IL-8	[122]
Sgouras et al	2004	L. casei Shirota	10⁸ CFU/mL, 9 months	C57BL/6 mice	Reducing H. pylori colonization and decrease specific IgG titer	[69]
Henry et al	2004	L. rhamnosus R0011, L. acidophilus R0052	10⁹ CFU/mL, 9 weeks	C57BL/6 mice	Anti-H. pylori effects Reduce gastric inflammation	[71]
Pena et al	2005	L. reuteri 1602, L. paracasei 6798	10⁹ CFU/mL, 12 weeks	C57BL/6 mice	Reducing the TNF-α and IL-12 levels	[123]
Sgouras et al	2005	L. johnsonii La1 L. amylovorus CDE471 L. acidophilus IBB 801	1.5–4 × 10⁸ CFU/mL, 3 months	C57BL/6 mice	Reducing H. pylori colonization and decrease gastric inflammation	[137]
Brzozowski et al	2006	L. acidophilus R0052 L. rhamnosus R0011	2 × 10⁹ CFU/mL, 2 weeks	Mongolian gerbil	Reduction gastrin and gastric inflammation	[138]
Chenoll et al	2011	B. bifidum CECT 7366	10⁹ CFU/mL	C57BL/6 mice	Blocking colonization of H. pylori	[139]
Kuo et al	2013	L. acidophilus, B. lactis	5 × 10⁹ CFU/mL	Mongolian gerbil	Reduction of gastric inflammation	[140]
Kaur et al	2014	P. acidilactici BA28	10⁹ CFU/mL, 24 weeks	C57BL/6 mice	Anti-H. pylori	[141]
Kim et al	2014	P. pentosaseus (SL4)	10⁸ CFU/mL, 6 weeks	C57BL/6 mice	Anti-H. pylori	[142]
Zaman et al	2014	L. reuteri L. johnsonii L. murinus	10⁹ CFU/mL	Mongolian gerbil	Anti-H. pylori	[143]
Matsui et al	2015	L. gasseri SBT2055	10⁹ CFU/mL	C57BL/6 mice	Production of specific IgA, Blocking progression of MALT	[144]
Yu et al	2015	E. faecalis B. longum L. acidophilus	10⁷ CFU/mL	C57BL/6 mice	Reducing gastric inflammation	[145]
Pan et al	2016	L. plantarum ZDY 2013	10⁹ CFU/mL	C57BL/6 mice	Reducing gastric inflammation	[146]
Afsahi et al	2018	L. plantarum ATCC8014	10⁶ CFU/mL, 2 weeks	C57BL/6 mice	Anti-H. pylori Reduction of gastric inflammation	[147]
Chen et al	2018	L. rhamnosus JB3	5 × 10⁷ CFU/mL	C57BL/6 mice	Anti-H. pylori Reduction of gastric inflammation	[148]
Merino et al	2018	L. fermentum UCO-979C	10⁷ CFU/mL	Mongolian gerbil	Inhibited H. pylori SS1	[149]
Lin et al	2020	L. fermentum P2 (P2), L. casei L21 (L21), L. rhamnosus JB3 (JB3)	10⁷ CFU/mL	C57BL/6 mice	Reduction of gastric inflammation	[150]

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