Table 2 Characteristics of patients who developed active tuberculosis during anti-TNF therapy
No | IBD | Sex | Age of anti-TNF (years) | Age of TB (years) | Interval to TB diagnosis (months) | Anti-TNF agents | TST | IGRA | Previous TB treatment | LTBI | TB prophylaxis | Smoking | TB site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | UC | M | 67 | 68 | 2 | IFX | ND | (−) | No | (−) | ND | Ex | Lung |
2 | UC | M | 66 | 67 | 10 | IFX | (−) | (−) | No | (−) | ND | Ex | Lung + peritoneum |
3 | UC | F | 42 | 47 | 55 | IFX | (−) | (−) | No | (−) | ND | (−) | Lung |
4 | UC | M | 53 | 53 | 2 | IFX | ND | (−) | No | (−) | ND | Ex | Lung |
5 | UC | M | 46 | 47 | 14 | IFX > ADA | ND | (+) | No | (+) | INH + RFP | Ex | Lung + pleura |
6 | UC | M | 60 | 60 | 4 | IFX | (−) | (−) | No | (−) | ND | (+) | pleura + pericardium |
7 | CD | F | 33 | 33 | 3 | IFX | (−) | (−) | No | (−) | ND | Ex | Lung |
8 | CD | M | 59 | 59 | 3 | IFX | (−) | (−) | No | (−) | ND | Ex | Lung |
9 | CD | M | 26 | 29 | 34 | ADA | (−) | (+) | No | (+) | INH + RFP | (−) | Lung |
10 | CD | F | 26 | 30 | 50 | IFX > ADA | (−) | (−) | No | (−) | ND | (−) | Lung |
11 | CD | M | 23 | 25 | 27 | IFX | ND | (−) | No | (−) | ND | (−) | Lung + LN |
12 | CD | F | 32 | 32 | 4 | IFX | ND | ND | No | Unknown | ND | (−) | Spleen + LN |
13 | CD | F | 22 | 25 | 42 | IFX | (−) | (+) | No | (+) | RFP | (−) | Lung |
14a | CD | F | 37 | 42 | 67 | IFX | (−) | (−) | No | (−) | ND | (+) | Lung + pleura |
15 | CD | M | 24 | 32 | 95 | IFX | (−) | (−) | ITBb | (−) | ND | (+) | Lung + pleura |
16 | CD | M | 29 | 30 | 5 | IFX | (−) | Indeterminate | No | (−) | ND | (−) | Lung |
17 | CD | F | 44 | 45 | 14 | IFX | (−) | (−) | No | (−) | ND | (−) | Lung |
18 | CD | M | 41 | 43 | 17 | IFX | (−) | (−) | Lung | (−) | ND | (−) | Lung |
19 | CD | F | 41 | 43 | 24 | IFX > ADA | (−) | (−) | ITBb | (−) | ND | (−) | pleura |
20 | CD | F | 35 | 36 | 11 | IFX | (−) | (−) | ITBb | (−) | ND | (−) | Lung + endobronchus |
21 | CD | M | 25 | 26 | 1 | IFX | ND | (−) | No | (−) | ND | (+) | Lung |