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Table 2 Characteristics of patients who developed active tuberculosis during anti-TNF therapy

From: Risk and characteristics of tuberculosis after anti-tumor necrosis factor therapy for inflammatory bowel disease: a hospital-based cohort study from Korea

No IBD Sex Age of anti-TNF (years) Age of TB (years) Interval to TB diagnosis (months) Anti-TNF agents TST IGRA Previous TB treatment LTBI TB prophylaxis Smoking TB site
1 UC M 67 68 2 IFX ND (−) No (−) ND Ex Lung
2 UC M 66 67 10 IFX (−) (−) No (−) ND Ex Lung + peritoneum
3 UC F 42 47 55 IFX (−) (−) No (−) ND (−) Lung
4 UC M 53 53 2 IFX ND (−) No (−) ND Ex Lung
5 UC M 46 47 14 IFX > ADA ND (+) No (+) INH + RFP Ex Lung + pleura
6 UC M 60 60 4 IFX (−) (−) No (−) ND (+) pleura + pericardium
7 CD F 33 33 3 IFX (−) (−) No (−) ND Ex Lung
8 CD M 59 59 3 IFX (−) (−) No (−) ND Ex Lung
9 CD M 26 29 34 ADA (−) (+) No (+) INH + RFP (−) Lung
10 CD F 26 30 50 IFX > ADA (−) (−) No (−) ND (−) Lung
11 CD M 23 25 27 IFX ND (−) No (−) ND (−) Lung + LN
12 CD F 32 32 4 IFX ND ND No Unknown ND (−) Spleen + LN
13 CD F 22 25 42 IFX (−) (+) No (+) RFP (−) Lung
14a CD F 37 42 67 IFX (−) (−) No (−) ND (+) Lung + pleura
15 CD M 24 32 95 IFX (−) (−) ITBb (−) ND (+) Lung + pleura
16 CD M 29 30 5 IFX (−) Indeterminate No (−) ND (−) Lung
17 CD F 44 45 14 IFX (−) (−) No (−) ND (−) Lung
18 CD M 41 43 17 IFX (−) (−) Lung (−) ND (−) Lung
19 CD F 41 43 24 IFX > ADA (−) (−) ITBb (−) ND (−) pleura
20 CD F 35 36 11 IFX (−) (−) ITBb (−) ND (−) Lung + endobronchus
21 CD M 25 26 1 IFX ND (−) No (−) ND (+) Lung
  1. TNF, tumor necrosis factor; IBD, inflammatory bowel disease; UC, ulcerative colitis; CD, Crohn’s disease; LTBI, latent tuberculosis infection; TB, tuberculosis; TST, tuberculin skin test; IGRA, interferon gamma release assay; IFX, infliximab; ADA, adalimumab; ND, not done; ITB, intestinal tuberculosis; INH, isoniazid; RFP, rifampin; Ex, ex-smoker; LN, lymph node
  2. aThis patent was undergoing treatment for tuberculosis at the end of the study. All other patients were completely cured after tuberculosis treatment
  3. bThese patients with Crohn's disease had a history of medication for tuberculosis to identify intestinal tuberculosis