|
Performance characteristic
|
Sensitivity of CRC detection in complete cohort (Model #1)
|
Sensitivity of CRC or HRA detection in residual cohort (Model #2) (%)
|
|---|
|
100%
|
99%
|
95%
|
|---|
|
% missed CRC
|
0
|
0
|
0.58
|
80
|
|
% missed HRA
|
6.2
|
7.2
|
13.7
| |
|
% colonoscopies avoided
|
16.4
|
18.7
|
31.3
| |
|
% missed CRC
|
0
|
0.58
|
0.58
|
70
|
|
% missed HRA
|
9.5
|
10.5
|
20.7
| |
|
% colonoscopies avoided
|
23.8
|
25.5
|
40.9
| |
|
% missed CRC
|
0
|
0.58
|
0.58
|
60
|
|
% missed HRA
|
12.7
|
14.4
|
27.6
| |
|
% colonoscopies avoided
|
27.5
|
30.5
|
48.7
| |
- Interpretation (100% Column, 80% row): At minimum probability cut points to permit 100% CRC detection in Model #1 and 80 CRC/HRA detection in Model #2, application of the sequential modelling strategy predicts a miss rate of 0% for CRC and 6.2% for HRA and reduces colonoscopy burden by 16.4%
