Table 3 The optimal cutoff values of CK18 for the prediction of significant fibrosis, advanced fibrosis and cirrhosis
CK18 | Significant fibrosis (F0-1 vs F2-4) | Advanced fibrosis (F0-2 vs F3-4) | Cirrhosis (F0-3 vs F4) |
|---|---|---|---|
AUROC (95%CI) | 0.86 (0.80, 0.93) | 0.75 (0.66, 0.83) | 0.84 (0.79, 0.89) |
Cutoff values (ng/L) | 90.5 | 90.5 | 104 |
Sensitivity/specificity (%) | 82/81 | 84/54 | 77/83 |
Correctly classified (%) | 82 | 72 | 78 |
PPV/NPV (%) | 95/54 | 74/68 | 94/52 |
Positive/negative LR | 4.42/0.22 | 1.81/0.30 | 4.45/0.28 |