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Table 3 The optimal cutoff values of CK18 for the prediction of significant fibrosis, advanced fibrosis and cirrhosis

From: Cytokeratin 18 can help predict liver fibrosis in HCV infected patients with type 2 diabetes mellitus

CK18 Significant fibrosis (F0-1 vs F2-4) Advanced fibrosis (F0-2 vs F3-4) Cirrhosis (F0-3 vs F4)
AUROC (95%CI) 0.86 (0.80, 0.93) 0.75 (0.66, 0.83) 0.84 (0.79, 0.89)
Cutoff values (ng/L) 90.5 90.5 104
Sensitivity/specificity (%) 82/81 84/54 77/83
Correctly classified (%) 82 72 78
PPV/NPV (%) 95/54 74/68 94/52
Positive/negative LR 4.42/0.22 1.81/0.30 4.45/0.28
  1. Numbers in parentheses are the 95% confidence interval
  2. AUROC, area under the receiver operating characteristic; CK18, cytokeratin 18; LR, likelihood ratio; NPV, negative predictive value; PPV, positive predictive value