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Table 4 Univariate and multivariate analyses of clinicopathological factors affecting DFS after resection of BTC

From: A combined prediction model for biliary tract cancer using the prognostic nutritional index and pathological findings: a single-center retrospective study

Factor

Univariate analysis

Multivariate analysis

n

P-value

HR (95% CI)

P-value

Age (years)

 

0.316

–

–

  ≥ 75

60

   

  < 75

56

   

Sex

 

0.078

–

–

 Male

73

   

 Female

43

   

BMI (kg/m2)

 

0.294

–

–

  ≥ 20

80

   

  < 20

36

   

CEA level (ng/mL)

 

0.413

–

–

  ≥ 9

17

   

  < 9

99

   

CA19-9 level (U/mL)

  

1.21 (0.63–2.47)

0.556

  ≥ 20

56

0.009**

  

  < 20

60

   

Preoperative cholangitis

 

0.027*

1.18 (0.57–2.40)

0.644

 Present

43

   

 Absent

73

   

Comorbidities

 

0.184

–

–

 Present

82

   

 Absent

34

   

Primary disease

 

0.060

–

–

 ICC

30

   

 GBC

29

   

 Distal cholangiocarcinoma

27

   

 Ampullary carcinoma

17

   

 Perihilar cholangiocarcinoma

13

   

Surgical procedure

 

0.115

–

–

 Cholecystectomy

11

   

 Bile duct resection w/o liver resection

1

   

 Minor hepatectomy

25

   

 Major hepatectomy

35

   

 Pancreaticoduodenectomy

42

   

 Hepatopancreaticoduodenectomy

2

   

Resection

 

 < 0.001***

2.35 (0.44–43.51)

 

 R0

98

  

0.604

 R1–2

18

   

Operation time (min)

 

0.006**

1.07 (0.521–2.20)

0.851

  ≥ 360

82

   

  < 360

34

   

Blood loss (mL)

 

0.478

–

–

  ≥ 200

81

   

  < 200

35

   

Transfusion

  

–

–

 No

100

0.293

  

 Yes

16

   

T stage

 

 < 0.001***

1.79 (0.78–4.17)

0.171

  < 3

57

   

  ≥ 3

59

   

N stage

 

 < 0.001***

1.30 (0.62–2.89)

0.449

 0

69

   

 1

47

   

Tumor differentiation

 

0.001**

2.19 (1.16–4.24)

0.016*

 Well

48

   

 Other

68

   

PNI

 

0.008**

1.29 (0.58–3.08)

0.540

  < 42

28

   

  ≥ 42

88

   

GPS

  

–

–

 0

44

0.126

  

 1–2

72

   

CAR

 

0.012*

1.29 (0.64–2.50)

0.469

  < 1

65

   

  ≥ 1

51

   

NLR

 

0.500

–

–

  < 2.55

85

   

  ≥ 2.55

31

   

PLR

 

0.269

–

–

  < 119

68

   

  ≥ 119

48

   

Postoperative complications (Clavien–Dindo grade ≥ IIIa)

 

0.449

–

–

 Absent

73

   

 Present

43

   

Postoperative adjuvant chemotherapy

 

0.222

–

–

 No

36

   

 Yes

80

   
  1. BMI body mass index, BTC biliary tract cancer, CA19-9 carbohydrate antigen 19-9, CEA carcinoembryonic antigen, CI confidence interval, CAR CRP to albumin ratio, CRP C-reactive protein, GBC gallbladder carcinoma, GPS Glasgow Prognostic Score, HR hazard ratio, ICC intrahepatic cholangiocarcinoma, NLR neutrophil to lymphocyte ratio, OS overall survival, PLR platelet to lymphocyte ratio, PNI prognostic nutritional index
  2. *P < 0.05; **P < 0.01; ***P < 0.001
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BMC Gastroenterology

ISSN: 1471-230X

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