|
Liver
|
Abnormal liver enzymes, asymptomatic hepatomegaly, acute or chronic hepatitis, cirrhosis, hepatic encephalopathy, and fulminant hepatitis [4]
|
|
Nervous system
|
Motor dysfunctions: dystonia, Parkinsonism, choreoathetosis, tremor, ataxia, dysarthria, oropharyngeal dysfunction; seizures [21]
|
| |
Nonmotor symptoms: school failure, personality disorders, mood changes, psychosis, cognitive abnormalities, sleep disorders, and autonomic disturbances, impulsiveness, sexual exhibitionism, inappropriate behavior [21]
|
|
Ophthalmologic manifestations
|
Kayser–Fleischer ring; sunflower cataract [22]; slowing of saccades, impaired upgaze, and strabismus
|
|
Blood
|
Hemolytic anemia (Coombs-negative hemolytic anemia) [23]; thrombocytopenia; HELLP syndrome; leukopenia
|
|
Kidney
|
Glomerulonephritis; nephrotic syndrome; renal tubular function disorder (renal tubular acidosis, aminoaciduria) [24]; IgA nephropathy [12]; IgM nephropathy [8]; Fanconi syndrome [25]; nephrolithiasis [26]
|
|
Musculoskeletal and joint diseases
|
Osteoporosis; osseomuscular; arthritis or arthralgias [27]; muscle weakness [28]
|
|
Endocrine system
|
Male feminization; paramenia [29]; habitual abortion [30]; infertility, sexual retardation [31]; hyperprolactinemia; hypoparathyroidism; insulinoma [32]; hypokalemia
|
|
Cardiovascular system
|
Electrocardiographic abnormalities; cardiac interstitial fibrosis [33], myocarditis [33]
|
|
Others
|
Pancreatitis [34]; cholangitis [35]; hyperpigmentation [36]; acanthosis nigricans [37]
|
