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Table 4 Effect of combination of age and Gender on the predictive capability of malignancy in patients with uncomplicated dyspepsia (n = 4037)

From: Age is the only predictor for upper gastrointestinal malignancy in Chinese patients with uncomplicated dyspepsia: a prospective investigation of endoscopic findings

  Age Gender Gender for malignancy
F F M M
< 50 > 50 Female Male < 57 > 57 < 56 > 56
Total n. patients 2553 1484 2397 1640 1857 540 1266 374
Malignancy (n, 45) 4 41 12 33 1 11 5 28
OR 1.12 4.40 1.12 1.12
[95% CI] [1.09, 1.15] [2.24, 8.62] [1.06, 1.18] [1.08, 1.16]
AUC 0.775 0.665 0.841 0.871
[95% CI] [0.721, 0.829] [0.651, 0.680] [0.826, 0.856] [0.854, 0.887]
Sensitivity 91.11% 73.33% 91.67% 84.85%
[95% CI] [78.8, 97.5] [58.1, 85.4] [61.5, 99.8] [68.1, 94.9]
Specificity 65.53% 59.74% 77.82% 78.47%
[95% CI] [64.0, 67.0] [58.2, 61.3] [76.1, 79.5] [76.4—80.5]
LR+ 2.64 1.82 4.13 3.94
[95% CI] [2.4, 2.9] [1.5, 2.2] [3.4, 5.0] [3.3—4.7]
LR- 0.14 0.45 0.11 0.19
[95% CI] [0.05, 0.3] [0.3, 0.7] [0.02, 0.7] 0.09—0.4
  1. OR odd ratios, AUC area under curve, 95% CI confidence interval, LR likelihood