|
APCN expression
|
HR (95% CI)
|
p-value
|
N (events)
|
HR (95% CI)
|
p-value
|
N (events)
|
|---|
| |
Univariable
| | |
Multivariable
| | |
|---|
|
Test series
| | |
357 (154)
| | |
356 (154)
|
|
Low
|
1.00
| | |
1.00
| | |
|
Moderate
|
1.71 (1.21–2.42)
|
0.003
| |
1.41 (0.99–2.01)
|
0.060
| |
|
High
|
1.90 (1.20–2.99)
|
0.006
| |
1.60 (1.01–2.53)
|
0.047
| |
|
Validation series
| | |
238 (81)
| | |
221 (72)
|
|
Low
|
1.00
| | |
1.00
| | |
|
Moderate
|
1.43 (0.86–2.37)
|
0.17
| |
1.26 (0.72–2.23)
|
0.42
| |
|
High
|
2.34 (1.33–4.14)
|
0.003
| |
2.22 (1.18–4.18)
|
0.013
| |
- CI confidence interval, HR Hazard ratio. Multivariable analysis included adjustment for sex, Dukes class for test series and TNM4-stage for validation series, differentiation grade (G1–2 vs. G3–4), and age (as continuous). Age and TNM-stage/Dukes-classification also remained as independent predictors of prognosis in the multivariable mode
