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Table 1 Cox uni- and multivariable analysis of the relative risk of death from colon cancer based on APCN expression

From: Elevated tumor expression of Astroprincin (FAM171A1) is an independent marker of poor prognosis in colon cancer

APCN expression HR (95% CI) p-value N (events) HR (95% CI) p-value N (events)
  Univariable    Multivariable   
Test series    357 (154)    356 (154)
Low 1.00    1.00   
Moderate 1.71 (1.21–2.42) 0.003   1.41 (0.99–2.01) 0.060  
High 1.90 (1.20–2.99) 0.006   1.60 (1.01–2.53) 0.047  
Validation series    238 (81)    221 (72)
Low 1.00    1.00   
Moderate 1.43 (0.86–2.37) 0.17   1.26 (0.72–2.23) 0.42  
High 2.34 (1.33–4.14) 0.003   2.22 (1.18–4.18) 0.013  
  1. CI confidence interval, HR Hazard ratio. Multivariable analysis included adjustment for sex, Dukes class for test series and TNM4-stage for validation series, differentiation grade (G1–2 vs. G3–4), and age (as continuous). Age and TNM-stage/Dukes-classification also remained as independent predictors of prognosis in the multivariable mode