Table 2 Univariate and multivariate analyses of prognostic factors that influence recurrence of MANEC in the gastric and ampullary
Variables | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
No. of patients (%) | MDFS (months) | P value | Hazard ratio (95%CI) | P value | |
Age (years) | |||||
< 60 | 16 | 20.0 | 0.402 | ||
≥ 60 | 16 | – | |||
Sex | |||||
Male | 26 | – | 0.272 | ||
Female | 6 | 15.0 | |||
Tumor location | |||||
Stomach | 25 | – | 0.324 | ||
Ampullary | 7 | 20.0 | |||
Tumor size | |||||
≤ 3 cm | 14 | – | 0.036 | 1.942 [0.606, 6.223] | 0.264 |
> 3 cm | 18 | 12.0 | |||
T | |||||
T1/T2 | 7 | – | 0.030 | 3.611 [0.335, 38.888] | 0.290 |
T3/T4 | 25 | 22.0 | |||
Lymph node metastasis | |||||
No | 8 | – | 0.013 | 8.380 [1.096, 64.094] | 0.041 |
Yes | 24 | 20.0 | |||
TNM stage | |||||
I/II | 10 | – | 0.015 | 0.797 [0.082, 7.792] | 0.846 |
III/IV | 22 | 20.0 | |||
Ki67 (%) | |||||
≤ 20 | 3 | 22.0 | 0.638 | ||
> 20 | 29 | 26.0 | |||
Cell type of NEC | |||||
Large cell | 11 | – | 0.612 | ||
Non-large cell | 21 | 25.0 | |||
Lymphatic invasion | |||||
Presence | 27 | 22.0 | 0.027 | – | 0.975 |
Absence | 5 | – | |||
Vascular invasion | |||||
Presence | 23 | 20.0 | 0.006 | 9.923 [1.298, 75.864] | 0.027 |
Absence | 9 | – | |||
Perineural invasion | |||||
Presence | 22 | 22.0 | 0.364 | ||
Absence | 10 | – | |||
Grade of adenocarcinoma | |||||
Well/moderate differentiation | 20 | – | 0.000 | 6.331 [2.046, 19.587] | 0.001 |
Poor/signet ring cell/mucin | 12 | 9.0 | |||
Syn | |||||
(+) | 31 | 25.0 | 0.397 | ||
(−) | 1 | – | |||
CgA | |||||
(+) | 26 | 26.0 | 0.668 | ||
(−) | 6 | 25.0 | |||
CD56 | |||||
(+) | 18 | – | 0.017 | 0.318 [0.112, 0.906] | 0.032 |
(−) | 14 | 9.0 | |||
PCK | |||||
(+) | 18 | 26.0 | 0.913 | ||
(−) | 14 | 22.0 | |||
EMA | |||||
(+) | 11 | 25.0 | 0.713 | ||
(−) | 21 | 26.0 | |||
CK7 | |||||
(+) | 8 | 20.0 | 0.515 | ||
(−) | 24 | 26.0 | |||
Chemotherapy | |||||
Yes | 11 | 26.0 | 0.71 | ||
No | 21 | 25.0 | |||