Skip to main content

Table 1 The clinical and pathological characteristics of MANEC in the gastric and ampullary

From: Mixed adenoneuroendocrine carcinomas of stomach and ampulla of vater after curative-intent resection: a single center cases series

Variables MANEC (n = 32)
Age, years, median (range) 59.5 (48–74)
Sex, male/female, n 26/6
AFP, ng/ml, median (range) 3.23 (1.04–64.65)
AFP > 20 ng/ml, n (%) 2 (6.2%)
CA19-9, U/ml, median (range) 12.82 (0.91–866.8)
CA19-9 > 40 U/ml, n (%) 5 (15.6%)
CEA, ng/ml, median (range) 3.12 (0.93–86.67)
CEA > 8 ng/ml, n (%) 5 (15.6%)
Tumor location, n  
 Ampulla of Vater 7
 Stomach 25
Tumor size < 3 cm/>3 cm 14/18
T, n (%)  
 T1 1 (3.1%)
 T2 6 (18.8%)
 T3 16 (50.0%)
 T4 9 (28.1%)
Lymph node metastasis, n (%) 24(75.0%)
TNM stage*, n (%)  
 I 2(15.6%)
 II 5 (15.6%)
 III 24 (65.7%)
 IV 1 (3.1%)
Ki67 median (range) 50.0% (10.0–90.0%)
Cell type of NEC, n (%)  
 Large cell 11 (34.4%)
 Mixed cell 14 (43.8%)
 Small cell 7 (21.8%)
Lymphatic invasion yes/no 27/5
Angioinvasion yes/no 18/14
Perineural invasion yes/no 20/12
Differentiation of adenocarcinoma, n (%)  
 Well differentiation 3 (9.3%)
 Moderate differentiation 12 (37.5%)
 Poor differentiation 10 (31.3%)
Signet ring cell/Mucin 7 (21.9%)
Syn (+), n (%) 31 (96.9%)
CgA (+), n (%) 26 (81.3%)
CD56 (+), n (%) 18(56.3%)
EMA(+), n (%) 11 (34.4%)
PCK(+), n (%) 18 (56.3%)
CK7(+), n (%) 8 (25.0%)
Chemotherapy, n (%) 11 (34.4%)
  1. MANEC Mixed adenoneuroendocrine carcinomas
  2. *AJCC TNM staging system of tumors (7th edition, 2010)