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Table 3 Clinical characteristics of patients with NBNC-HCC who underwent hepatic resection

From: Increasing incidence of non-HBV- and non-HCV-related hepatocellular carcinoma: single-institution 20-year study

 

NASH

Alcoholic liver disease

Cryptogenic etiology

P value

NASH versus Alcoholic liver disease

NASH versus cryptogenic etiology

Alcoholic liver disease versus cryptogenic etiology

n = 29

n = 57

n = 108

Age (years)

66 (47–82)

71 (54–88)

73 (25–85)

0.040

0.018

N.S

Sex (male/female)

14/15

55/2

84/21

< 0.001

< 0.001

0.004

Body mass index (kg/m2)

24.4 (17.4–31.3)

23.6 (15.2–32.4)

23.5 (16.0–34.2)

NS

NS

NS

Antibody to hepatitis B core antigen

10 (34.4%)

17 (29.8%)

34 (31.4%)

NS

NS

NS

Diabetes mellitus

13 (44.8%)

30 (54.3%)

64 (59.2%)

NS

NS

NS

Hypertension

17 (58.6%)

34 (59.6%)

71 (65.7%)

NS

NS

NS

Hyperlipidemia

8 (25.5%)

15 (26.3%)

36 (33.3%)

NS

NS

NS

AST (IU/L)

53 (19–397)

56 (19–146)

39 (15–308)

NS

0.041

0.035

ALT (IU/L)

58 (17–435)

45 (11–175)

38 (8–340)

0.035

0.032

0.043

γ-GTP (IU/L)

74 (21–612)

82 (18–836)

70 (8–583)

NS

NS

NS

Platelet counts (× 104/μL)

15.4 (7–23.6)

15.1 (5.2–29.1)

18.4 (6.1–43.3)

NS

0.025

0.023

FIB-4 index

3.68 (1.03–17.52)

3.28 (1.40–11.37)

2.56 (0.47–8.66)

NS

< 0.001

0.002

ALBI grade 1/2/3

17/9/3

38/17/2

74/32/2

NS

NS

NS

  1. Continuous data are presented as medians and range, and categorical data are presented as numbers of patients
  2. AST aspartate aminotransferase, ALT alanine aminotransferase; γ-GTP γ-Glutamytranspeptidase, NASH non-alcoholic steatohepatitis, FIB-4 fibrosis-4, ALBI grade albumin-bilirubin grade, NS not significant