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Table 3 Clinical characteristics of patients with NBNC-HCC who underwent hepatic resection

From: Increasing incidence of non-HBV- and non-HCV-related hepatocellular carcinoma: single-institution 20-year study

  NASH Alcoholic liver disease Cryptogenic etiology P value
NASH versus Alcoholic liver disease NASH versus cryptogenic etiology Alcoholic liver disease versus cryptogenic etiology
n = 29 n = 57 n = 108
Age (years) 66 (47–82) 71 (54–88) 73 (25–85) 0.040 0.018 N.S
Sex (male/female) 14/15 55/2 84/21 < 0.001 < 0.001 0.004
Body mass index (kg/m2) 24.4 (17.4–31.3) 23.6 (15.2–32.4) 23.5 (16.0–34.2) NS NS NS
Antibody to hepatitis B core antigen 10 (34.4%) 17 (29.8%) 34 (31.4%) NS NS NS
Diabetes mellitus 13 (44.8%) 30 (54.3%) 64 (59.2%) NS NS NS
Hypertension 17 (58.6%) 34 (59.6%) 71 (65.7%) NS NS NS
Hyperlipidemia 8 (25.5%) 15 (26.3%) 36 (33.3%) NS NS NS
AST (IU/L) 53 (19–397) 56 (19–146) 39 (15–308) NS 0.041 0.035
ALT (IU/L) 58 (17–435) 45 (11–175) 38 (8–340) 0.035 0.032 0.043
γ-GTP (IU/L) 74 (21–612) 82 (18–836) 70 (8–583) NS NS NS
Platelet counts (× 104/μL) 15.4 (7–23.6) 15.1 (5.2–29.1) 18.4 (6.1–43.3) NS 0.025 0.023
FIB-4 index 3.68 (1.03–17.52) 3.28 (1.40–11.37) 2.56 (0.47–8.66) NS < 0.001 0.002
ALBI grade 1/2/3 17/9/3 38/17/2 74/32/2 NS NS NS
  1. Continuous data are presented as medians and range, and categorical data are presented as numbers of patients
  2. AST aspartate aminotransferase, ALT alanine aminotransferase; γ-GTP γ-Glutamytranspeptidase, NASH non-alcoholic steatohepatitis, FIB-4 fibrosis-4, ALBI grade albumin-bilirubin grade, NS not significant