| |
1992–2009
|
2010–2018
|
P value
|
|---|
|
n = 204
|
n = 310
|
2010–2018 versus 1992–2009
|
|---|
|
Age (years)
|
67 (21–85)
|
72 (22–90)
|
< 0.001
|
|
Sex (male/female)
|
163/41
|
254/56
|
NS
|
|
Alcohol consumption
|
127 (62.2%)
|
203 (65.4%)
|
NS
|
|
Antibody to hepatitis B core antigen
|
83 (40.6%)
|
96 (30.9%)
|
0.023
|
|
Body mass index (kg/m2)
|
23.8 (14.3–38.9)
|
23.9 (15.3–41.2)
|
NS
|
|
Diabetes mellitus
|
99 (48.5%)
|
187 (60.3%)
|
0.008
|
|
Hypertension
|
99 (48.5%)
|
178 (57.4%)
|
0.046
|
|
Hyperlipidemia
|
80 (39.2%)
|
167 (53.8%)
|
0.001
|
|
ALT (IU/L)
|
47 (8–435)
|
48 (6–388)
|
NS
|
|
Platelet counts (× 104/μL, median)
|
15.1 (3.5–49.1)
|
17.9 (2.7–57.3)
|
0.013
|
|
FIB-4 index
|
4.37 (0.67–28.31)
|
3.61 (0.25–22.34)
|
0.026
|
|
ALBI grade 1/2/3
|
93/96/15
|
138/146/26
|
NS
|
|
Child–Pugh grade A/B/C
|
151/42/11
|
231/63/16
|
NS
|
|
Antinuclear antibody
|
23 (11.2%)
|
45 (14.5%)
|
NS
|
|
Antimitochondrial antibodies
|
9 (4.4%)
|
6 (1.9%)
|
NS
|
- Continuous data are presented as medians and range, and categorical data are presented as numbers of patients
- NBNC negative for hepatitis B surface antigen and antibody to hepatitis C virus, ALT alanine aminotransferase, FIB-4 fibrosis-4; ALBI grade albumin-bilirubin grade, NS not significant
