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Table 2 Characteristics of patients with NBNC-HCC stratified according to dates of study period

From: Increasing incidence of non-HBV- and non-HCV-related hepatocellular carcinoma: single-institution 20-year study

  1992–2009 2010–2018 P value
n = 204 n = 310 2010–2018 versus 1992–2009
Age (years) 67 (21–85) 72 (22–90) < 0.001
Sex (male/female) 163/41 254/56 NS
Alcohol consumption 127 (62.2%) 203 (65.4%) NS
Antibody to hepatitis B core antigen 83 (40.6%) 96 (30.9%) 0.023
Body mass index (kg/m2) 23.8 (14.3–38.9) 23.9 (15.3–41.2) NS
Diabetes mellitus 99 (48.5%) 187 (60.3%) 0.008
Hypertension 99 (48.5%) 178 (57.4%) 0.046
Hyperlipidemia 80 (39.2%) 167 (53.8%) 0.001
ALT (IU/L) 47 (8–435) 48 (6–388) NS
Platelet counts (× 104/μL, median) 15.1 (3.5–49.1) 17.9 (2.7–57.3) 0.013
FIB-4 index 4.37 (0.67–28.31) 3.61 (0.25–22.34) 0.026
ALBI grade 1/2/3 93/96/15 138/146/26 NS
Child–Pugh grade A/B/C 151/42/11 231/63/16 NS
Antinuclear antibody 23 (11.2%) 45 (14.5%) NS
Antimitochondrial antibodies 9 (4.4%) 6 (1.9%) NS
  1. Continuous data are presented as medians and range, and categorical data are presented as numbers of patients
  2. NBNC negative for hepatitis B surface antigen and antibody to hepatitis C virus, ALT alanine aminotransferase, FIB-4 fibrosis-4; ALBI grade albumin-bilirubin grade, NS not significant