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Table 2 Characteristics of patients with NBNC-HCC stratified according to dates of study period

From: Increasing incidence of non-HBV- and non-HCV-related hepatocellular carcinoma: single-institution 20-year study

 

1992–2009

2010–2018

P value

n = 204

n = 310

2010–2018 versus 1992–2009

Age (years)

67 (21–85)

72 (22–90)

< 0.001

Sex (male/female)

163/41

254/56

NS

Alcohol consumption

127 (62.2%)

203 (65.4%)

NS

Antibody to hepatitis B core antigen

83 (40.6%)

96 (30.9%)

0.023

Body mass index (kg/m2)

23.8 (14.3–38.9)

23.9 (15.3–41.2)

NS

Diabetes mellitus

99 (48.5%)

187 (60.3%)

0.008

Hypertension

99 (48.5%)

178 (57.4%)

0.046

Hyperlipidemia

80 (39.2%)

167 (53.8%)

0.001

ALT (IU/L)

47 (8–435)

48 (6–388)

NS

Platelet counts (× 104/μL, median)

15.1 (3.5–49.1)

17.9 (2.7–57.3)

0.013

FIB-4 index

4.37 (0.67–28.31)

3.61 (0.25–22.34)

0.026

ALBI grade 1/2/3

93/96/15

138/146/26

NS

Child–Pugh grade A/B/C

151/42/11

231/63/16

NS

Antinuclear antibody

23 (11.2%)

45 (14.5%)

NS

Antimitochondrial antibodies

9 (4.4%)

6 (1.9%)

NS

  1. Continuous data are presented as medians and range, and categorical data are presented as numbers of patients
  2. NBNC negative for hepatitis B surface antigen and antibody to hepatitis C virus, ALT alanine aminotransferase, FIB-4 fibrosis-4; ALBI grade albumin-bilirubin grade, NS not significant