rs55646866 CC | rs55646866 CT | rs55646866 TT | p value (Fisher or Kruskal–Wallis) | |
---|---|---|---|---|
Gender | ||||
Male (n = 488) Female (n = 493) | 394 (50.2%) 391 (49.8%) | 81 (46.8%) 92 (53.2%) | 13 (56.5%) 10 (43.5%) | 0.605 |
Age at diagnosis [years] | ||||
Median, q25–q75, Min–max | 24.3, 17.9–34.4, 1.1–81.4 | 24.4, 18.5–33.0, 0.8–65.9 | 25.0, 18.7–31.5, 11.5–73.7 | 0.875 |
Disease duration [years] | ||||
Median, q25–q75, Min–max | 12.2, 7.0–20.9, 0.1–56.6 | 12.8, 7.6–23.5, 1.2–44.7 | 6.1, 4.5–13.1, 1.5–33.8 | 0.030 |
Complications* | ||||
No (n = 345) Yes (n = 636) | 281 (35.8%) 504 (64.2%) | 56 (32.4%) 117 (67.6%) | 8 (34.8%) 15 (65.2%) | 0.727 |
Fistula, abscess or anal fissure* | ||||
No (n = 518) Yes (n = 463) | 411 (52.4%) 374 (47.6%) | 94 (54.3%) 79 (45.7%) | 13 (56.5%) 10 (43.5%) | 0.836 |
Focus on the “yes”: | ||||
Perianal fistula Other fistula Fissure Abscess | 199 (53.2%) 144 (38.5%) 113 (30.2%) 203 (54.3%) | 38 (48.1%) 36 (45.6%) 24 (30.4%) 44 (55.7%) | 6 (60.0%) 3 (30.0%) 3 (30.0%) 6 (60.0%) | 0.641 0.439 1.000 0.930 |
Surgery | 195 (52.1%) | 46 (58.2%) | 5 (50.0%) | 0.626 |
Stenosis* | ||||
No (n = 551) Yes (n = 430) | 446 (56.8%) 339 (43.2%) | 95 (54.9%) 78 (45.1%) | 10 (43.5%) 13 (56.5%) | 0.413 |
Focus on the “yes”: | ||||
Operation Dilation No intervention | 169 (49.9%) 133 (39.2%) 189 (55.8%) | 44 (56.4%) 33 (42.3%) 40 (51.3%) | 8 (61.5%) 3 (23.1%) 7 (53.8%) | 0.460 0.434 0.766 |
CDAI—maximal value throughout follow-up | ||||
Median, q25–q75, Min–max | 64, 28–114, 0–435 | 76, 33–131, 6–479 | 64, 50–117, 6–280 | 0.108 |
Reported flare* | ||||
No (n = 477) Yes (n = 504) | 387 (49.3%) 398 (50.7%) | 82 (47.4%) 91 (52.6%) | 8 (34.8%) 15 (65.2%) | 0.365 |
Flare possibly or highly related to (focus on yes): | ||||
NSAIDs Antibiotics GI tract infection Other infection Treatment decr./disc Other medication | 8 (2.0%) 8 (2.0%) 63 (15.8%) 25 (6.3%) 100 (25.1%) 4 (1.0%) | 2 (2.2%) 0 (0%) 20 (22.0%) 11 (12.1%) 29 (31.9%) 3 (3.3%) | 1 (6.7%) 1 (6.7%) 1 (6.7%) 1 (6.7%) 5 (33.3%) 0 (0%) | 0.450 0.154 0.255 0.143 0.319 0.292 |
Flare management (focus on the yes): | ||||
Hospitalization Ambulatory Surgery Drug therapy | 68 (17.1%) 96 (24.1%) 39 (9.8%) 344 (86.4%) | 16 (17.6%) 31 (34.1%) 11 (12.1%) 81 (89.0%) | 2 (13.3%) 2 (13.3%) 0 (0%) 13 (86.7%) | 0.967 0.090 0.443 0.776 |
Focus on the hospitalizations: | ||||
Total days of hosp. Median, q25–q75, Min–max | 7.5, 2–16, 0–55 | 3.5, 0–17.5, 0–86 | 4, 3–5, 3–5 | 0.553 |