From: Impact of acute kidney injury on mortality in patients with acute variceal bleeding
All patients (n = 546) | No AKI (n = 393) | AKI (n = 153) | P | |
---|---|---|---|---|
Age, year | 58.0 (51.0–68.0) | 58.0 (51.5–68.0) | 58.0 (51.0–67.0) | 0.810 |
Male sex | 459 (84.1%) | 326 (83.0%) | 133 (86.9%) | 0.298 |
Bleeding source | 0.360 | |||
Esophageal varices | 425 (77.8%) | 310 (78.9%) | 115 (75.2%) | |
Gastric varices | 121 (22.2%) | 83 (21.1%) | 38 (24.8%) | |
Active bleeding at endoscopy | 232 (42.5%) | 161 (41.0%) | 71 (46.4%) | 0.250 |
Etiology | 0.538 | |||
Alcohol | 353 (64.7%) | 247 (62.8%) | 106 (69.3%) | |
HBV | 108 (19.8%) | 83 (21.1%) | 25 (16.3%) | |
HCV | 39 (7.1%) | 29 (7.4%) | 10 (6.5%) | |
Cryptogenic | 46 (8.4%) | 34 (8.7%) | 12 (7.8%) | |
BMI, kg/m2 | 22.9 (20.7–25.0) | 22.9 (20.8–24.9) | 23.1 (20.5–25.3) | 0.602 |
Diabetes | 184 (33.7%) | 128 (32.6%) | 56 (36.6%) | 0.420 |
HCC | 82 (15.0%) | 44 (11.2%) | 38 (24.8%) | < 0.001 |
Child–Pugh classification | < 0.001 | |||
A | 158 (28.9%) | 133 (33.8%) | 25 (16.3%) | |
B | 265 (48.5%) | 198 (50.4%) | 67 (43.8%) | |
C | 123 (22.5%) | 62 (15.8%) | 61 (39.9%) | |
MELD score | 12.0 (10.0–18.0) | 11.0 (9.0–14.0) | 19.0 (14.0–25.0) | < 0.001 |
Ascites | 293 (53.7%) | 199 (50.6%) | 94 (61.4%) | 0.028 |
Encephalopathy | 49 (9.0%) | 23 (5.9%) | 26 (17.0%) | < 0.001 |
Diuretics | 177 (32.5%) | 116 (29.6%) | 61 (39.9%) | 0.025 |
Hemoglobin, g/dL | 8.7 (7.5–10.0) | 9.0 (7.7–10.2) | 8.0 (6.9–9.0) | < 0.001 |
Platelet, × 109/L | 84.5 (59.0–118.3) | 84.0 (69.5–113.0) | 85.0 (55.0–133.0) | 0.602 |
PT-INR | 1.43 (1.26–1.69) | 1.37 (1.25–1.57) | 1.69 (1.42–2.08) | < 0.001 |
Bilirubin, mg/dL | 1.43 (0.89–2.67) | 1.30 (0.83–2.30) | 1.87 (1.01–4.00) | < 0.001 |
Albumin, g/dL | 2.9 (2.5–3.4) | 3.0 (2.6–3.4) | 2.7 (2.2–3.0) | < 0.001 |
sCr at admission, mg/dL | 0.79 (0.64–1.00) | 0.73 (0.63–0.89) | 1.12 (0.84–1.58) | < 0.001 |
Baseline sCr, mg/dL | 0.71 (0.61–0.86) | 0.71 (0.60–0.84) | 0.75 (0.62–0.92) | 0.009 |
Failure to control bleeding | 32 (5.9%) | 11 (2.8%) | 21 (13.7%) | < 0.001 |
Variceal rebleeding | 38 (7.0%) | 27 (6.9%) | 11 (7.2%) | 0.854 |