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Table 4 Assays performance according to the RT-PCR assay

From: The prevalence of HEV among non-A-C hepatitis in Qatar and efficiency of serological markers for the diagnosis of hepatitis E

Kit

Overall agreement % (95% CI)

Sensitivity % (95% CI)

Specificity % (95% CI)

PPV % (95% CI)

NPV % (95% CI)

Cohen’s Kappa value (CI)

Wantai HEV-Ag

81.1 (70.7–88.4)

36.7 (16.3–56.5)

100.0 (100–100)

100.00 (100–100)

78.7 (68.9–88.7)

0.44 (0.22–0.66)

Wantai HEV-IgM

91.0 (83.8–95.2)

71.4 (52.1–90.8)

96.20 (91.9–100)

83.3 (66.1–100.5)

92.6 (87.0–98.3)

0.71 (0.53–0.88)

Wantai HEV-IgG

70.3 (60.8–78.3)

63.64(43.5–83.7)

72.15 (62.3–82.0)

38.8 (22.9–54.8)

87.6 (79.7–95.6)

0.29 (0.10–0.48)

MP HEV-Total Ab

73.2 (61.9–82.1)

77.27 (59.8–94.8)

71.43 (58.8–84.1)

54.8 (37.3–72.3)

87.5 (77.2–97.7)

0.44 (0.23–0.64)

  1. The overall percent agreement is the percentage of total subjects where the new test and the non-reference standard agree
  2. PPV positive predictive value, NPV negative predictive value