Table 1 Baseline characteristics of the study population according to the BCLC stage
Variables | All patients (n = 80) | BCLC 0 (n = 15, 18.8%) | BCLC A (n = 38, 47.5%) | BCLC BCD (n = 27, 33.7%) |
|---|---|---|---|---|
Age, years | 62.5 (56.0–70.0) | 63.3 (58.5–69.0) | 64.2 (57.5–71.0) | 59.6 (53.0–66.5) |
Male gender | 60 (75.0) | 10 (66.7) | 30 (78.9) | 20 (74.1) |
Etiology | ||||
Hepatitis B virus | 48 (60.0) | 9 (60.0) | 20 (52.6) | 19 (70.4) |
Hepatitis C virus | 7 (8.8) | 2 (13.3) | 4 (10.5) | 1 (3.7) |
Alcohol | 13 (16.2) | 1 (6.7) | 9 (23.7) | 3 (11.1) |
Others | 12 (15.0) | 3 (20.0) | 5 (13.2) | 4 (14.8) |
Liver cirrhosis | 64 (80.0) | 12 (80.0) | 28 (73.7) | 24 (88.9) |
Child–Pugh class | ||||
A | 62 (77.5) | 15 (100) | 31 (81.6) | 16 (59.3) |
B or C | 18 (22.5) | 0 (0) | 7 (18.4) | 11 (40.7) |
Total bilirubin, mg/dL | 1.44 (0.70–1.20) | 0.67 (0.35–0.95) | 1.14 (0.70–1.15) | 2.24 (0.80–2.05) |
Albumin, g/dL | 3.9 (3.4–4.3) | 4.0 (3.5–4.5) | 3.9 (3.5–4.5) | 3.7 (3.4–4.1) |
Aspartate aminotransferase, IU/L | 70.7 (33.0–80.0) | 48.9 (23.5–56.0) | 48.1 (31.0–59.5) | 111.8 (54.5–126.5) |
Alanine aminotransferase, IU/L | 44.6 (19.0–52.0) | 31.5 (14.0–42.0) | 37.7 (18.5–44.5) | 60.4 (28.5–54.5) |
Platelet count, 109/L | 144.8 (97.0–181.0) | 126.9 (76.0–155.0) | 144.8 (87.5–195.0) | 154.1 (116.5–185.0_ |
Prothrombin time, INR | 1.12 (1.03–1.17) | 1.08 (0.99–1.14) | 1.11 (1.01–1.20) | 1.14 (1.04–1.22) |
Alpha-fetoprotein, ng/mL | 7620.9 (4.4–439.8) | 91.0 (2.4–61.2) | 3712.8 (3.6–74.6) | 16,695.1 (92.5–69,082.0) |
PIVKA-II, mAU/mL | 6918.1 (18.0–649.0) | 32.9 (58.5–69.0) | 506.9 (57.5–71.0) | 18,961.3 (53.0–66.5) |
Type of treatment | ||||
Resection | 31 (38.8) | 7 (46.7) | 18 (47.4) | 6 (22.2) |
Radiofrequency ablation | 25 (31.2) | 6 (40.0) | 18 (47.4) | 1 (3.7) |
Transarterial chemoembolization | 8 (10.0) | 2 (13.3) | 2 (5.3) | 4 (14.8) |
Sorafenib | 5 (6.2) | 0 (0) | 0 (0) | 5 (18.5) |
Radiation therapy | 1 (1.2) | 0 (0) | 0 (0) | 1 (3.7) |
Transarterial radioembolization | 3 (3.8) | 0 (0) | 0 (0) | 3 (11.1) |
Conservative treatment | 7 (8.8) | 0 (0) | 0 (0) | 7 (25.9) |