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Fig. 4 | BMC Gastroenterology

Fig. 4

From: Selective inhibition of soluble TNF using XPro1595 relieves pain and attenuates cerulein-induced pathology in mice

Fig. 4

Soluble TNF activity reduces hindpaw mechanical hyper-sensitivity following induction of acute pancreatitis in mice. Graph shows mechanical hypersensitivity of the hindpaw when touched by von Frey filaments, as a percentage of pre-cerulein baseline data for each mouse. No differences were observed in hypersensitivity of non-pancreatitis mice between baseline and on days 3, 5 and 7, independent of treatment (n = 6–8). In contrast, vehicle-treated pancreatitis mice displayed significantly more hypersensitivity than non-pancreatitis control mice at each time point assessed during the first week (n = 9). Treating mice with XPro1595 prevented this hypersensitivity at all time-points tested (n = 9), and this group displayed significantly less hypersensitivity than the vehicle-treated pancreatitis group on the last 2 days of testing. NC non-cerulein, C cerulein, V vehicle, XP XPro1595, *p < 0.05, ***p < 0.001

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