Fig. 3

Immunohistochemical staining for IMP3 in patients with papillary adenocarcinoma. a A tumor endoscopically resected from a patient with T1 adenocarcinoma without infiltrating in the sphincter of Oddi: The IMP3-positive cell rate was approximately 5% in this tumor. b A tumor surgically resected from a patient with T2 adenocarcinoma: The IMP3 positive cell rate was approximately 20% in this tumor. c A tumor surgically resected from a patient with T3 adenocarcinoma: The IMP3-positive cell rate was approximately 50% in this tumor. IMP3-positive cells are expressed on the tumor surface in B and C. d A biopsy specimen: The IMP3-positive cell rate is approximately 80% in this sample. Surgical operation was performed, and the final pathological diagnosis was T2 adenocarcinoma. IMP3 insulin-like growth factor 2 messenger RNA–binding protein 3