Table 3 Significant predictors of survival
Variables | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
HR (95% CI)* | p Value | HR (95% CI) | p Value | ||
Age | < 65 | 1.97 (1.12–3.46) | 0.017 | ||
≥ 65 | 1 | ||||
Sex | Male | 1.25 (0.45–3.49) | 0.661 | ||
Female | 1 | ||||
ECOG | 0, 1 | 1 | |||
2 | 1.39 (0.18–6.67) | 0.732 | |||
Prior treatment | No | 0.96 (0.51–1.81) | 0.893 | ||
Yes | 1 | ||||
Tumor distribution | Unilobar | 0.87 (0.43–0.98) | 0.044 | 0.10 (0.02–0.75) | 0.012 |
Bilobar | 1 | ||||
Portal vein invasion | No | 0.61 (0.35–1.06) | 0.083 | ||
Yes | 1 | ||||
Index lesion size (cm) | ≤ 10 | 0.39 (0.22–0.67) | 0.001 | 0.92 (0.26–3.21) | 0.672 |
> 10 | 1 | ||||
Tumor burden† (%) | ≤ 50 | 0.18 (0.07–0.43) | 0.001 | 0.94 (0.58–9.52) | 0.733 |
50–75 | 1 | ||||
Alpha-fetoprotein | < 100 | 0.63 (0.38–1.05) | 0.072 | ||
≥ 100 | 1 | ||||
Child–Pugh class | Child A | 1 | |||
Child B | 1.27 (0.40–4.06) | 0.691 | |||
BCLC stage‡ | BCLC B | 0.48 (0.26–0.89) | 0.018 | 0.43 (0.12–1.15) | 0.317 |
BCLC C | 1 | ||||
Radiologic response (mRECIST§) | CR/PR | 0.14 (0.06–0.32) | 0.001 | 0.09 (0.03–0.29) | 0.001 |
SD/PD | 1 | ||||