Schistosoma mansoni-related periportal fibrosis; can we use APRI and PSDR levels in the real-time selection of patients for targeted endoscopy in a resource-limited setting? A case–control study

Table 4 Predictive values of APRI, PSDR, and combined APRI-PSDR levels for portal varices

Variable	Cut point	Derivation cohort (N = 250)			Validation cohort (N = 200)
Variable	Cut point	ROC	Sense (95% CI)	Spec (95% CI)	ROC	Sense (95% CI)	Spec (95%CI)
APRI	1.51	0.8259	82.5 (74.1–89.2)	80.1 (72.6–86.3)	0.8117	84.0 (75.0–91.0)	72.0 (62–80.0)
PSDR	5700	0.6471	73.4 (64.1–81.4)	75.2 (67.2–82.1)	0.7431	74.5 (64.4–83.0)	73.0 (63.1–81.0)
APRI-PSDR	NA	NA	54.1(44.3–63.7)	94.3 (89.1–97.5)	NA	71.3 (61.0–80.1)	71.0 (61.1–79.1)

APRI: Aspartate aminotransferase-platelet index; CI: confidence interval; NA: not applicable; PSDR: Platelet splenic diameter ratio; ROC: receiver operating curve; APRI-PSDR: combined APRI and PSDR value

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