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Table 2 Logistic regression analysis for ICU mortality

From: Lower serum chloride concentrations are associated with increased risk of mortality in critically ill cirrhotic patients: an analysis of the MIMIC-III database

 

Univariable

p value

Multivariable

p value

Chloride, per 1 mEq/L increase

0.96 (0.94–0.97)

< 0.001

0.94 (0.91–0.98)

0.002

Sodium, per 1 mEq/L increase

0.97 (0.95–0.99)

0.010

1.03 (0.99–1.08)

0.119

Age per year increase

1.01 (1.00–1.02)

0.098

1.02 (1.01–1.04)

0.002

Gender

 Female

1 [Reference]

 

1 [Reference]

 

 Male

0.83 (0.62–1.13)

0.234

0.86 (0.60–1.24)

0.422

Ethnicity

 Other

1 [Reference]

 

1 [Reference]

 

 White

0.52 (0.37–0.73)

< 0.001

0.73 (0.47–1.13)

0.155

 Black

0.64 (0.36–1.17)

0.150

1.03 (0.49–2.19)

0.935

 Hispanic

0.20 (0.08–0.51)

0.001

0.40 (0.13–1.18)

0.098

ICU type

 MICU

1 [Reference]

   

 SICU/TSICU

0.89 (0.64–1.23)

0.481

  

 CCU/CSRU

1.14 (0.70–1.85)

0.604

  

Etiology of cirrhosis

 Non-alcoholic

1 [Reference]

   

 Alcoholic

1.28 (0.96–1.70)

0.097

  

Elixhauser comorbidity index, per point increase

1.03 (1.02–1.04)

< 0.001

1.01 (0.99–1.02)

0.243

MELD score, per point increase

1.10 (1.09–1.12)

< 0.001

1.04 (1.01–1.06)

0.007

SOFA score, per point increase

1.39 (1.32–1.45)

< 0.001

1.20 (1.12–1.30)

< 0.001

Mechanical ventilation

 No

1 [Reference]

 

1 [Reference]

 

 Yes

3.29 (2.4–4.48)

< 0.001

2.61 (1.74–3.90)

< 0.001

Vasopressors

 No

1 [Reference]

 

1 [Reference]

 

 Yes

4.81 (3.55–6.53)

< 0.001

1.42 (0.93–2.17)

0.103

Renal replacement therapy

 No

1 [Reference]

 

1 [Reference]

 

 Yes

5.60 (3.15–9.97)

< 0.001

0.63 (0.30–1.32)

0.221

Acute kidney injury

 No

1 [Reference]

 

1 [Reference]

 

 Yes

3.81 (2.77–5.23)

< 0.001

1.56 (1.03–2.37)

0.037

Hemoglobin, per 1 g/dL increase

0.90 (0.83–0.97)

0.005

0.94 (0.86–1.03)

0.189

Platelet, per 1 × 109/L increase

1.00 (1.00–1.00)

0.004

1.00 (1.00–1.00)

0.473

White blood cell, per 1 × 109/L increase

1.05 (1.03–1.07)

< 0.001

1.04 (1.01–1.06)

0.008

  1. CCU, coronary care unit; CSRU, cardiac surgery care unit; ICU, intensive care unit; MELD, Model for End-stage Liver Disease; MICU, medical intensive care unit; SICU, surgical intensive care unit; SOFA, Sequential Organ Failure Assessment; TSICU, traumatic surgical intensive care unit