Extent of disease affects the usefulness of fecal biomarkers in ulcerative colitis

BMC Gastroenterology

Table 5 Summary of predictive values of fecal biomarkers for endoscopic remission (MES 0 vs. 1, 2, 3)

FC	AUC	Cut-off value	Sensitivity	Specificity	PPV	NPV	Accuracy
All cases	0.821	290	0.713	0.885	0.911	0.651	0.778
Pancolitis	0.866	344	0.761	0.909	0.921	0.732	0.823
Left-side colitis	0.836	192	0.781	0.941	0.970	0.64	0.828
Proctitis	0.649	270	0.571	0.818	0.8	0.6	0.68

FIT	AUC	Cut-off value	Sensitivity	Specificity	PPV	NPV	Accuracy
All cases	0.858	45	0.762	0.902	0.928	0.696	0.815
Pancolitis	0.835	42	0.804	0.879	0.902	0.763	0.835
Left-side colitis	0.913	46	0.805	0.941	0.971	0.667	0.845
Proctitis	0.825	25	0.714	0.909	0.909	0.714	0.8

FL	AUC	Cut-off value	Sensitivity	Specificity	PPV	NPV	Accuracy
All cases	0.855	79	0.733	0.918	0.937	0.675	0.802
Pancolitis	0.894	79	0.783	0.909	0.923	0.75	0.835
Left-side colitis	0.870	65	0.756	0.941	0.969	0.615	0.810
Proctitis	0.698	98	0.5	0.909	0.875	0.588	0.68

FC fecal calprotectin, FIT fecal immunochemical test for hemoglobin, FL fecal lactoferrin, AUC area under the curve, PPV positive predictive value, NPV negative predictive value

ISSN: 1471-230X