Variables | PFS | |||
---|---|---|---|---|
Univariate | Multivariate | |||
Hazard ratio* | P | Hazard ratio* | P | |
Age (years) | Â | Â | Â | Â |
  ≤ 60 | 1.00 |  |  |  |
  > 60 | 1.07 (0.83–1.38) | 0.613 |  |  |
BMI (kg/m2) | Â | Â | Â | Â |
  ≤ 23.9 | 1.00 |  | 1.00 |  |
  > 23.9 | 0.72 (0.55–0.94) | 0.015 | 0.83 (0.63–1.09) | 0.184 |
Gender | Â | Â | Â | Â |
 Male | 1.00 |  |  |  |
 Female | 1.02 (0.75–1.39) | 0.903 |  |  |
ASA score | Â | Â | Â | Â |
 1 | 1.00 |  |  |  |
 2 | 1.23 (0.76–2.00) | 0.402 |  |  |
 3 | 1.39 (0.79–2.46) | 0.255 |  |  |
ECOG (per 1 increase) | 1.61 (1.32–1.96) |  < 0.001 | 1.27 (1.01–1.60) | 0.043 |
Comorbidities | Â | Â | Â | Â |
 No | 1.00 |  |  |  |
 Yes | 1.13 (0.87–1.48) | 0.363 |  |  |
Location | Â | Â | Â | Â |
 Localized | 1.00 | 0.383 |  |  |
 Diffused | 3.81 (2.44–5.94) |  < 0.001 |  |  |
Location | Â | Â | Â | Â |
 Upper | 1.00 |  | 1.00 |  |
 Middle | 1.10 (0.73–1.66) | 0.633 | 1.44 (0.93–2.23) | 0.100 |
 Lower | 0.94 (0.70–1.27) | 0.686 | 1.25 (0.90–1.72) | 0.181 |
 Diffused | 3.74 (2.31–6.08) |  < 0.001 | 1.77 (1.02–3.08) | 0.044 |
Diameter (cm) | Â | Â | Â | Â |
  ≤ 2 | 1.00 |  | 1.00 |  |
 2–5 | 1.96 (1.47–2.62) |  < 0.001 | 1.15 (0.85–1.55) | 0.364 |
  > 5 | 4.30 (2.99–6.17) |  < 0.001 | 1.92 (1.26–2.95) | 0.003 |
Differentiation | Â | Â | Â | Â |
 Well-moderate | 1.00 |  | 1.00 |  |
 Poor | 1.32 (0.98–1.77) | 0.064 | 1.03 (0.77–1.39) | 0.833 |
Lymphovascular invasion | Â | Â | Â | Â |
 No | 1.00 |  |  |  |
 Yes | 2.94 (2.27–3.81) |  < 0.001 |  |  |
ypT | Â | Â | Â | Â |
 T0 | 1.00 |  |  |  |
 T1 | 1.68 (0.57–4.93) | 0.342 |  |  |
 T2 | 2.11 (0.79–5.64) | 0.138 |  |  |
 T3 | 3.94 (1.56–9.94) | 0.004 |  |  |
 T4 | 7.04 (2.89–17.16) |  < 0.001 |  |  |
ypN | Â | Â | Â | Â |
 N0 | 1.00 |  |  |  |
 N1 | 1.95 (1.30–2.93) | 0.001 |  |  |
 N2 | 3.01 (2.02–4.47) |  < 0.001 |  |  |
 N3 | 7.46 (5.28–10.53) |  < 0.001 |  |  |
ypTNM stage | Â | Â | Â | Â |
 0 | 1.00 | 1.00 | 1.00 |  |
 I | 0.94 (0.33–2.63) | 0.901 | 0.92 (0.33–2.61) | 0.880 |
 II | 2.36 (0.94–5.95) | 0.067 | 1.98 (0.782–5.02) | 0.150 |
 III | 7.76 (3.19–18.91) |  < 0.001 | 5.32 (2.15–13.20) |  < 0.001 |
Resection type | Â | Â | Â | Â |
 Subtotal | 1.00 |  |  |  |
 Total | 1.76 (1.36–2.28) |  < 0.001 |  |  |
Adjuvant chemotherapy | Â | Â | Â | Â |
 Yes | 1.00 |  | 1.00 |  |
 No | 1.58 (1.16–2.15) | 0.003 | 1.42 (1.03–1.96) | 0.034 |
Cycle of NACT | Â | Â | Â | Â |
  > 3 | 1.00 |  |  |  |
  ≤ 3 | 1.39 (0.85–2.28) | 0.192 |  |  |
Clavien–Dindo |  |  |  |  |
 Grade 0–II | 1.00 |  | 1.00 |  |
 Grade III–IV | 1.36 (0.97–1.91) | 0.073 | 1.03 (0.71–1.47) | 0.889 |
CEA | Â | Â | Â | Â |
  ≤ 5.72 | 1.00 |  |  |  |
  > 5.72 | 2.30 (1.70–3.11) |  < 0.001 |  |  |
CA199 | Â | Â | Â | Â |
  ≤ 15.00 | 1.00 |  |  |  |
  > 15.00 | 1.71 (1.32–2.21) |  < 0.001 |  |  |
CA724 | Â | Â | Â | Â |
  ≤ 2.60 | 1.00 |  |  |  |
  > 2.60 | 1.81 (1.38–2.38) |  < 0.001 |  |  |
Post-NACT CTM | Â | Â | Â | Â |
 0 | 1.00 |  | 1.00 |  |
 1 | 1.54 (1.06–2.23) | 0.022 | 1.37 (0.94–2.00) | 0.099 |
 2 | 2.77 (1.87–4.10) |  < 0.001 | 2.07 (1.37–3.10) |  < 0.001 |
 3 | 4.54 (2.85–7.22) |  < 0.001 | 3.11 (1.91–5.07) |  < 0.001 |