Table 3 Predictive performances of nomograms, APRI, FIB-4, and GPR for advanced fibrosis (S3-S4) and cirrhosis (S4) (Validation cohort)

From: Nomogram for predicting advanced liver fibrosis and cirrhosis in patients with chronic liver disease

Indexes	AUROC (95%CI)	P	Cutoff	Se (%)	Sp (%)
S3–S4
NomogramS3S4	0.86 (0.82–0.90)	< 0.0001	0.41	70.0	87.1
APRI	0.79 (0.73–0.83)	< 0.0001	0.51	91.2	47.0
FIB-4	0.78 (0.72–0.82)	< 0.0001	1.48	72.5	68.6
GPR	0.81 (0.76–0.85)	< 0.0001	0.23	97.5	28.9
S4
NomogramS4	0.88 (0.83–0.92)	< 0.0001	0.91	54.0	95.9
APRI	0.77 (0.72–0.82)	< 0.0001	0.66	92.0	53.6
FIB-4	0.81 (0.76–0.85)	< 0.0001	2.34	58.0	84.4
GPR	0.83 (0.78–0.87)	< 0.0001	0.38	94.0	46.4

AUROC, area under ROC; Se, sensitivity; Sp, specificity

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