From: Is insulin the preferred treatment in persons with type 2 diabetes and liver cirrhosis?
Variables | Before propensity score match | After propensity score match | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Non-insulin users (n = 17,173) | Insulin users (n = 2047) | p value | Non-insulin users (n = 4094) | Insulin users (n = 2047) | p value | |||||
N | % | N | % | n | % | n | % | |||
Age | 0.01 | 0.54 | ||||||||
18–49 | 5886 | 34.27 | 732 | 35.76 | 1444 | 35.27 | 732 | 35.76 | ||
50–65 | 7301 | 42.51 | 900 | 43.97 | 1793 | 43.80 | 900 | 43.97 | ||
> 65 | 3986 | 23.22 | 415 | 20.27 | 857 | 20.93 | 415 | 20.27 | ||
Mean ± SD | 55.37 ± 11.91 | 54.98 ± 11.32 | 0.15 | 55.20 ± 11.82 | 54.98 ± 11.32 | 0.29 | ||||
Sex | 0.11 | 0.62 | ||||||||
Female | 5421 | 31.57 | 611 | 29.85 | 1197 | 29.24 | 611 | 29.85 | ||
Male | 11,752 | 68.43 | 1436 | 70.15 | 2897 | 70.76 | 1436 | 70.15 | ||
DM age, mean ± SD | 55.96 ± 11.12 | 51.93 ± 10.93 | < 0.0001 | 52.58 ± 11.03 | 51.93 ± 10.93 | 0.06 | ||||
DM duration, mean ± SDa | 4.85 ± 3.47 | 3.05 ± 2.79 | < 0.0001 | 3.21 ± 3.94 | 3.05 ± 2.79 | 0.10 | ||||
Antihypertensive drugs | ||||||||||
ACEI/ARB | 7401 | 43.10 | 1076 | 52.56 | < 0.0001 | 2143 | 52.34 | 1076 | 52.56 | 0.87 |
β-blockers | 9004 | 52.43 | 1298 | 63.41 | < 0.0001 | 2567 | 62.70 | 1298 | 63.41 | 0.59 |
Calcium-channel blockers | 5086 | 29.62 | 777 | 37.96 | < 0.0001 | 1495 | 36.52 | 777 | 37.96 | 0.27 |
Diuretics | 4304 | 25.06 | 699 | 34.15 | < 0.0001 | 1384 | 33.81 | 699 | 34.15 | 0.79 |
Other anti-hypertensive agent | 3350 | 19.51 | 521 | 25.45 | < 0.0001 | 1034 | 25.26 | 521 | 25.45 | 0.87 |
Antidiabetic drugs | ||||||||||
Metformin | 5437 | 31.66 | 1033 | 50.46 | < 0.0001 | 2036 | 49.73 | 1033 | 50.46 | 0.59 |
Sulfonylurea | 6446 | 37.54 | 1178 | 57.55 | < 0.0001 | 2337 | 57.08 | 1178 | 57.55 | 0.73 |
Meglitinide | 1814 | 10.56 | 327 | 15.97 | < 0.0001 | 644 | 15.73 | 327 | 15.97 | 0.80 |
Thiazolidinedione | 2050 | 11.94 | 429 | 20.96 | < 0.0001 | 789 | 19.27 | 429 | 20.96 | 0.12 |
α-glucosidase inhibitor | 1779 | 10.36 | 341 | 16.66 | < 0.0001 | 644 | 15.73 | 341 | 16.66 | 0.35 |
DPP-4 inhibitors | 457 | 2.66 | 92 | 4.49 | < 0.0001 | 199 | 4.86 | 92 | 4.49 | 0.53 |
Other drugs | ||||||||||
Statin | 4202 | 24.47 | 661 | 32.29 | < 0.0001 | 1299 | 31.73 | 661 | 32.29 | 0.66 |
Aspirin | 9556 | 55.65 | 1354 | 66.15 | < 0.0001 | 2762 | 67.46 | 1354 | 66.15 | 0.30 |
DCSI score | < 0.0001 | 0.59 | ||||||||
0 | 9298 | 54.14 | 732 | 35.76 | 1418 | 34.64 | 732 | 35.76 | ||
1 | 2595 | 15.11 | 397 | 19.39 | 786 | 19.20 | 397 | 19.39 | ||
≥ 2 | 5280 | 30.75 | 918 | 44.85 | 1890 | 46.17 | 918 | 44.85 | ||
CCI | < 0.0001 | 0.64 | ||||||||
0 | 11,657 | 67.88 | 694 | 33.90 | 1357 | 33.15 | 694 | 33.90 | ||
1 | 2326 | 13.54 | 528 | 25.79 | 1101 | 26.89 | 528 | 25.79 | ||
≥ 2 | 3190 | 18.58 | 825 | 40.31 | < 0.0001 | 1636 | 39.96 | 825 | 40.30 | |
HBV | 2810 | 16.36 | 491 | 23.99 | < 0.0001 | 928 | 22.67 | 491 | 23.99 | 0.25 |
HCV | 2093 | 12.19 | 407 | 19.88 | < 0.0001 | 804 | 19.64 | 407 | 19.88 | 0.82 |