Fig. 1

Markov model diagrams for patients undergoing monotherapy and combination therapy. Five health states exist: stable disease (SD), treatment complication (TC), progression, progression with complication (PC) and death. Each circles represents different health states. Patients in the model move between the health states following the direction of the arrow and assigned transition-probabilities for every model-cycle. Circular arrows indicate transition-probability for remaining in the same state for the next model-cycle. Death is the absorbing state