Mortality rates and risk factors in 1412 Japanese patients with decompensated hepatitis C virus-related cirrhosis: a retrospective long-term cohort study

Table 3 Predictive factors of mortality in the 569 patients with decompensated HCV-related cirrhosis without HCC

Factor	Category	Univariate analysis			Multivariate analysis
Factor	Category	HR	95% CI	P-value^a	HR	(95% CI)	P-value^a
Demographic
Sex	Male	1
	Female	1.18	0.96–1.46	0.1176
Age, years	< 65	1			1
	≥ 65	1.71	1.38–2.12	< 0.001	1.81	1.44–2.26	< 0.001
Child–Pugh classification	B	1			1
	C	1.92	1.35–2.72	< 0.001	1.98	1.35–2.90	< 0.001
Esophageal varices	No	1
	Yes	1.12	0.95–1.37	0.3230
Laboratory
eGFR, mL/min	≥ 84	1			1
	< 84	1.68	1.36–2.08	< 0.001	1.69	1.36–2.11	< 0.001
Sodium, mEq/L	≥ 141	1
	< 141	1.20	0.97–1.48	0.0999
AFP, μg/L	< 18.5	1
	≥ 18.5	0.76	0.61–0.94	0.123

AFP, alpha-fetoprotein; CI, confidence interval; eGFR, estimated glomerular filtration rate; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; HR, hazard ratio
^aSignificance was determined using the Cox proportional hazard model. The four variables that were significant in the univariate analysis were entered into the multivariate analysis to identify significant independent factors

ISSN: 1471-230X