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Table 4 CNV region associated with NAFLD

From: Identifying potential biomarkers of nonalcoholic fatty liver disease via genome-wide analysis of copy number variation

Region Gene Sample frequency (gains, losses) Function GO item Relevant study ( DOI)
Chr3:57199594-57590187 APPL1 1 (0, 1) Adiponectin, insulin signalling GO:0008286 10.1371/journal.pone.0071391
Chr7:54813380-55274871 EGFR 1 (0, 1) Tyrosine phosphorylation regulates cell proliferation GO:0000165 10.3969/j.issn.1674-4136.2017.05.016; 10.1016/j.bbadis.2017.10.016
Chr17:38688567-38738474 CCR7 2 (0, 2) Participates inflammatory response GO:0007249 10.1038/ijo.2017.200; 10.3870/j.issn.1672-0741.2017.06.011
Chr19:56370486-56416408 NLRP4 3 (0, 3) Inhibition of type I interferon and NF-KB inflammatory signalling GO:0032479 10.1186/s12876-014-0208-8; 10.1074/jbc.M200446200
Chr22:24347959-24390254 GSTT1 7 (6, 1) Participates in the phase II reaction and promote toxic metabolism GO:0004602 10.1016/j.clinre.2011.01.015
Chr14:74001651-74022324 ACOT1 2 (1, 1) Regulation of lipid metabolism enzyme activity GO:0071616 10.2337/db16-1519; 10.1194/jlr.M081455
Chr12:57897795-57918452 CHOP 1 (1, 0) Participates in endoplasmic reticulum stress and promote apoptosis GO:0036488 10.1038/labinvest.2016.61; 10.1016/j.ejps.2011.02.005
Chr1:65935075-65959904 LEPR 1 (0, 1) Regulates leptin signalling GO:0038021 10.2174/1566524018666180705110412; 10.3870/lcxh.j.issn.1005-541X.2011.03.07
Chr20:33470663-33495348 ACSS2 1 (0, 1) Regulation of lipid metabolism enzyme activity GO:0006085 10.1073/pnas.1806635115; 10.1002/jcp.25954